IndraLab

Statements

KCNA2 activates MCF2L2. 10 / 10
| 10
reach
"Kv1.2 AS RNA up-regulation may be responsible for spinal nerve ligation (SNL) or CCI-induced down-regulation of Kv1.2 mRNA and protein in the injured DRG, resulting in a reduction in total Kv current and an increase in excitability in the injured large and medium DRG neurons [14;44]."
25630025
reach
"Blocking the SNL-induced increase in DRG DNMT3a via its genetic knockout or knockdown restored the expression of Kcna2, but not Kcna1 and Kcna4, in the injured DRG, whereas mimicking the SNL-induced increase in DRG DNMT3a via its genetic overexpression decreased the expression of Kcna2, but not Kcna4, in the DRG of naive rat."
28270689
reach
"For example, G9a-triggered histone methylation and endogenous long non-coding Kcna2 antisense RNA are involved in nerve injury-induced Kcna2 silencing in the injured DRG."
29056068
reach
"We found that MZF1 binds to this motif on the Kcna2 AS gene promoter in the DRG , and SNL time-dependently increases MZF1 expression and its binding activity in the injured DRG ."
24739997
reach
"To assess whether Kcna2 antisense RNA modulates DRG neuronal excitability, we carried out whole-cell current-clamp recording 8–12 weeks post-injection."
23792947
reach
"Our findings indicate that Kcna2 knockdown or current inhibition increases DRG neuronal excitability."
23792947
reach
"Electrophysiological experiments further identified that Kcna2 AS RNA reduced total Kv current and increased excitability of DRG neurons [19]."
30451044
reach
"Given that the promoter regions of Oprm1 (encoding MOR) and Kcna2 (encoding Kv1.2) do not contain the consensus binding motif of OCT1 , we conclude that the contribution of DRG OCT1 to neuropathic pain induction and maintenance may be mediated by epigenetic silencing of MOR and Kv1.2 caused by OCT1-triggered transcriptional activation of the Dnmt3a gene in the injured DRG."
30247265
reach
"Mimicking nerve injury-induced Kcna2 downregulation by overexpressing Kcna2 AS RNA in DRG reduced total Kv current, depolarized resting membrane potential, decreased current threshold for inducing AP, and increased the excitability in the DRG neurons and led to neuropathic pain-like behaviors41020."
27874088
reach
"We previously reported an antisense lncRNA, Kcna2 antisense RNA, which contributed to neuropathic pain by specific silencing of Kcna2 (or Kv1.2) expression in DRG."
27030721