IndraLab

Statements

AMPK_alpha binds USP10. 9 / 9
| 7 2
reach
"USP10 interacts with AMPK and deubiquitinates AMPKalpha."
26876938
reach
"As result, AMPKalpha interacts with USP10 and significantly inhibits polyubiquitylation of AMPKalpha in Hela cells."
30056112
reach
"Mechanistically, USP10 interacts and stabilizes PTEN and AMPKalpha by inhibiting their polyubiquitylation."
30056112
sparser
"As result, AMPKα interacts with USP10 and significantly inhibits polyubiquitylation of AMPKα in Hela cells ()."
30056112
sparser
"As USP10 binds to AMPKα and regulates AMPK activation, we hypothesized that USP10 might regulate AMPK activation through the deubiquitination of AMPKα."
26876938
reach
"Mechanistically, USP10 interacts with and stabilizes PTEN and AMPKalpha by inhibiting their polyubiquitylation, and subsequently suppresses the activity of mTOR signaling pathway."
30056112
reach
"Inversely, endogenous PTEN and AMPKalpha interacted with endogenous USP10 in HCC-LM3 and HUH7 cells."
30056112
reach
"Therefore, we conclude that USP10 interacts with PTEN and AMPKalpha, inhibits their polyubiquitylation, and as a result stabilizes PTEN and AMPKalpha.Next, we examined whether Rapamycin, a well known [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30056112
reach
"As USP10 binds to AMPKalpha and regulates AMPK activation, we hypothesized that USP10 might regulate AMPK activation through the deubiquitination of AMPKalpha."
26876938