IndraLab

Statements

COPS5 inhibits CREB3. 4 / 5
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"In the case of Luman, this regulatory mechanism does not seem plausible, since JAB1 repression of Luman was also observed in the GAL4 reporter system, in which Luman was recruited to the artificial GA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, JAB1 inhibited the activity of Luman/CREB3, which is an ER-bound transcription factor that has been implicated in the ER stress response by promoting its degradation [ 31–33 ]."
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"We found that JAB1 could repress the activation potential of Luman and decrease its protein stability.The Matchmaker 3 yeast two-hybrid system and a pre-transformed adult human brain Matchmaker cDNA l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here we show that, in a similar manner, JAB1 might also downregulate the transactivation activity of Luman during the UPR."
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