IndraLab

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E6 activates USP15. 2 / 2
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"Moreover, the human papillomavirus (HPV) E6 protein increases the activity of USP15 to promote proteasomal degradation of TRIM25, and Herpesvirus mediates autoubiquitination of TRIM25 to prevent K63 linked ubiquitination of RIG-I XREF_BIBR, XREF_BIBR."
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"For example, the non structural protein 1 (NS1) of influenza A virus displaces the SPRY domain by binding to an overlapping contact site on the CC domain [XREF_BIBR], the V proteins of measles, Sendai and parainfluenza viruses bind to the SPRY domain and prevent the interaction of TRIM25 with RIG-I [XREF_BIBR], while the E6 proteins of oncogenic HPVs target TRIM25 and USP15 to promote degradation of the ligase [XREF_BIBR]."
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