IndraLab

Statements

Parthenolide inhibits NLRP3. 38 / 38
| 3 31 4
reach
"Different NLRP3 inflammasome inhibitors, including sulforaphane, β-hydroxybutyrate, glyburide, flufenamic acid, mefenamic acid, parthenolide, BAY 11-7082, INF39, and MCC950 have been developed, but there is no evidence demonstrating that these compounds directly and specifically target NLRP3 itself (212)."
30619282
eidos
"OLT1177 , BOT-4-one , parthenolide , BAY 11-7082 , INF39 , and MCC950 could inhibit ATPase activity of NLRP3 ."
32693241
reach
"Separate to its effects on NFκB activation parthenolide has now also been shown to inhibit caspase-1 and NLRP3."
23305783
reach
"Parthenolide also directly inhibits NLRP3 by inhibiting its ATPase activity that is required for activation [ 55 ]."
23305783
reach
"Juliana and coworkers [70] reported that parthenolide at a concentration of 10 μM can selectively inhibit the ATPase activity of NLRP3 through binding to cysteine in the p20 subunit of caspase-1."
36234744
reach
"Parthenolide was a direct inhibitor of caspase-1 and NLRP3, representing a therapeutic approach against inflammatory diseases [164] ."
34089866
reach
"Parthenolide inhibits NLRP1, NLRC4, and NLRP3 stimuli by alkylating a number of cysteine residues of caspase-1 thus blocking caspase-1 activation."
33534121
reach
"Interestingly, in addition to its role in inhibiting caspase-1, parthenolide also directly inhibits NLRP3 by inhibiting its ATPase activity, which is required for activation of caspase-1."
25653548
reach
"For example, MCC950, CY-09, OLT1177/dapansutrile, MNS, and parthenolide inhibit NLRP3 by inhibiting its ATPase activity or modifying its ATPase domain38,48,54-57)."
33678767
eidos
"OLT1177 , BOT-4-one , parthenolide , BAY 11-7082 , INF39 , and MCC950 could inhibit ATPase activity of NLRP3 ."
| DOI
reach
"In a similar manner, parthenolide, a sesquiterpene lactone alkylating agent, alkylated the NACHT domain and inhibited the ATPase of NLRP3 (Juliana et al., 2010)."
36669831
reach
"MNS, parthenolide and BOT-4-one impair NLRP3 ATPase activity, thereby suppressing NLRP3 inflammasome activation."
36960868
reach
"Parthenolide inhibits the ATPase activity of NLRP3, which in turn decreases NLRP3 activity."
38882867
reach
"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."
29021150
reach
"Moreover, Parthenolide suppresses caspase-1 by causing alkylation of caspase-1 and limits NLRP3 by directly inhibiting its ATPase activity."
32703754
reach
"IL-1beta secretion was not affected by treatment with the NLRP3 inhibitor glyburide XREF_BIBR or parthenolide, which has also been shown to inhibit NLRP3 XREF_BIBR."
22216309
reach
"Parthenolide, BAY 11-7082, INF39, and MNS have been reported to directly inhibit NLRP3 ATPase activity, but these inhibitors have unspecific roles."
29021150
reach
"Parthenolide (PTL), a naturally occurring nuclear factor kappa B (NF-κB) inhibitor, is also known to inhibit NLRP3 inflammasome."
39327568
reach
"Glyburide and parthenolide both inhibited NLRP3 activation by LPS and ATP (data not shown)."
22216309
reach
"Besides, INF39, Parthenolide and BAY 11-7082 are also able to inhibit the ATPase activity of NLRP3, however, the detailed molecular mechanism is not yet fully understood (Juliana et al., 2010; Shi et al., 2021c)."
36619871
sparser
"For example, MCC950, CY-09, OLT1177/dapansutrile, MNS, and parthenolide inhibit NLRP3 by inhibiting its ATPase activity or modifying its ATPase domain xref , xref , xref - xref ."
33678767
reach
"The results showed that epalrestat, sulforaphane, parthenolide and OLT1177 could inhibit the activation of NLRP3 inflammasome at the concentration of 40 μmol/L, and epalrestat is more effective than OLT1177 at this concentration (Additional file 2)."
37805545
reach
"Parthenolide also impedes the ATPase activity of NLRP3 and the protease activity of caspase 1."
37047552
reach
"For example, taraxasterol and parthenolide suppress the activation of NLRP3 inflammasome by blocking the activation of NF-κB (126, 127), and celastrol resolves the inflammatory response to RA through inhibition of the ROS/NF-κB/NLRP3 axis (128)."
35833125
sparser
"Parthenolide also directly inhibits NLRP3 by inhibiting its ATPase activity that is required for activation [ 55 ]."
23305783
reach
"Parthenolide, a naturally occurring sesquiterpene lactone from Feverfew, and Bay 11-7082, a phenyl vinyl sulfone compound, disrupt the ATPase activity of NLRP3, concurrent with suppressed IκB kinase, NF-κB and caspase-1 activation [142,143,144]."
32545355
sparser
"Even, chemical inhibition of NLRP3 by parthenolide diminishes the occurrence of diabetes."
38710282
reach
"Parthenolide and Bay11-7082 also inhibited NLRP3 ATPase activity in vitro [112], but are unlikely to act as specific NLRP3 inhibitors due to their diverse biological activities."
38129399
reach
"Besides using antibodies against inflammasome components a recent study showed that Bay-11-7082 and Parthenolide, both NF-κB pathway inhibitors were able to inhibit NLRP3 receptor ATPase activity, whi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24103368
reach
"However, previously identified NF-kappaB inhibitors Bay 11-7082 and parthenolide were also shown to inhibit the second step of NLRP3 inflammasome activation [XREF_BIBR]."
27467658
reach
"One study has demonstrated that parthenolide inhibits multiple inflammasome pathways including NLRP3, NLRP1, and NLRC4 and directly inhibits caspase-1, but does not inhibit the AIM2 pathway (Juliana et al., 2010; Coll et al., 2011)."
35754962
eidos
"Parthenolide inhibits NLRP1 , NLRC4 , and NLRP3 stimuli by alkylating a number of cysteine residues of caspase-1 thus blocking caspase-1 activation ( Juliana et al. 2010 ) ."
33534121
reach
"Previous studies have reported that MNS, parthenolide, BAY 11-7082, and INF39 can inhibit the ATPase activity of NLRP3 and show inhibitory activity for NLRP3 inflammasome in vitro."
29021150
reach
"The underlying mechanisms of action of these molecules are diverse : BHB and glyburide prevent the decline of intracellular K + required for NLRP3 activation and ASC oligomerization XREF_BIBR, XREF_BIBR, whereas parthenolide and Bay 11-7082 inhibit NLRP3 ATPase activity 18."
30894604
sparser
"Bay 11–7082 and parthenolide directly inhibit NLRP3 and also inhibit caspase-1 activity, but are not suitable for clinical development due to the potential for widespread immunosuppression ( xref )."
35095918
reach
"Therefore, possible treatment for these diseases have been suggested by identifying therapeutic candidates such as miR-223, parthenolide, MCC950, and tranilast that block activation of NLRP3 inflammas[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31358323
reach
"The vinyl sulfone Bay 11-7082, the sesquiterpene lactone parthenolide, and the benzoxathiole derivative BOT-4-one all block the ATPase activity of NLRP3 [116,117]."
36555757
reach
"Even, chemical inhibition of NLRP3 by parthenolide diminishes the occurrence of diabetes."
38710282