IndraLab

Statements

KCNQ2 activates CD4. 5 / 5
| 5
reach
"Fusion of KCNQ2 C-terminal tail deficient in CaM binding fails to preferentially target CD4 to the axonal surface."
25077630
reach
"A previous report XREF_BIBR as well as our results (XREF_FIG, XREF_SUPPLEMENTARY) indicated that the membrane proximal region of the KCNQ2 C-terminal tail, upstream of the ankyrin-G binding domain, was sufficient to preferentially target CD4 to the axonal surface."
25077630
reach
"Using immunocytochemistry and the cluster of differentiation 4 (CD4) membrane protein as a trafficking reporter, we demonstrate that fusion of KCNQ2 carboxy-terminal tail is sufficient to target CD4 protein to the axonal surface whereas inhibition of calmodulin binding to KCNQ2 abolishes axonal surface expression of CD4 fusion proteins by retaining them in the endoplasmic reticulum."
25077630
reach
"Fusion of KCNQ2 C-terminal tail preferentially targets CD4 to the axonal surface."
25077630
reach
"These results together indicate that fusion of KCNQ2 C-terminal tail deficient in CaM binding fails to preferentially target CD4 to the axonal surface."
25077630