IndraLab

Statements

KCNMA1 activates EGFR. 17 / 17
| 10 7
sparser
"This response requires the EGFR that is activated very specifically by SLO."
21787862
reach
"This response requires the EGFR that is activated very specifically by SLO."
21787862
reach
"EGFR activation by SLO is as specific as, but distinct from, activation by EGF."
21787862
sparser
"EGFR activation by SLO is as specific as, but distinct from, activation by EGF."
21787862
reach
"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
21787862
sparser
"This could account for how the SLO activation of EGFR reported here produces significant inhibition of MDA-MB-231 cell invasion, whereas in previous reports EGF added to MDA-MB-231 cells had no effect, or produced some increase in invasion [ xref – xref ]."
21787862
reach
"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
21787862
sparser
"SLO activation of ErbB1 did not increase phosphorylation of ERK kinase, a hallmark of EGF signaling."
21787862
reach
"Independent experiments (n = 3) confirmed that 10 units/ml of recombinant SLO induced a significant (p < = 0.02) activation of EGFR in MDA-MB-231 cells compared to non treated control cells."
21787862
reach
"This dose dependent response corresponded to selective SLO activation of epidermal growth factor receptor (EGFR) ErbB1."
21787862
sparser
"This dose-dependent response corresponded to selective SLO activation of epidermal growth factor receptor (EGFR) ErbB1."
21787862
reach
"By comparison, SLO activation of EGFR yielded less intense staining than the internal standards."
21787862
reach
"The results show only ErbB1, but no other RTK, was activated by SLO, demonstrating a high degree of specificity."
21787862
reach
"Knockdown of EGFR by siRNA ablated the inhibitory effect of SLO on cancer cell invasion, showing SLO selectively activated ErbB1 kinase to reduce invasion without increasing cell growth."
21787862
sparser
"SLO activates the EGFR ErbB1 in MDA-MB-231 cancer cells."
21787862
reach
"This could account for how the SLO activation of EGFR reported here produces significant inhibition of MDA-MB-231 cell invasion, whereas in previous reports EGF added to MDA-MB-231 cells had no effect, or produced some increase in invasion [XREF_BIBR - XREF_BIBR]."
21787862
sparser
"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
21787862