IndraLab

Statements

KCNMA1 activates EGFR. 17 / 17
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"SLO activation of ErbB1 did not increase phosphorylation of ERK kinase, a hallmark of EGF signaling."
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"EGFR activation by SLO is as specific as, but distinct from, activation by EGF."
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"This could account for how the SLO activation of EGFR reported here produces significant inhibition of MDA-MB-231 cell invasion, whereas in previous reports EGF added to MDA-MB-231 cells had no effect, or produced some increase in invasion [XREF_BIBR - XREF_BIBR]."
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"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
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"This response requires the EGFR that is activated very specifically by SLO."
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"This response requires the EGFR that is activated very specifically by SLO."
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"This dose dependent response corresponded to selective SLO activation of epidermal growth factor receptor (EGFR) ErbB1."
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"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
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"SLO selectively activated only the EGF receptor ErbB1 (not ErbB2, 3, 4 that were also present on the array, in the same row), even in the constant presence of 10% fetal serum in the medium."
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"This dose-dependent response corresponded to selective SLO activation of epidermal growth factor receptor (EGFR) ErbB1."
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"This could account for how the SLO activation of EGFR reported here produces significant inhibition of MDA-MB-231 cell invasion, whereas in previous reports EGF added to MDA-MB-231 cells had no effect, or produced some increase in invasion [ xref – xref ]."
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"EGFR activation by SLO is as specific as, but distinct from, activation by EGF."
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"The results show only ErbB1, but no other RTK, was activated by SLO, demonstrating a high degree of specificity."
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"SLO activates the EGFR ErbB1 in MDA-MB-231 cancer cells."
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"By comparison, SLO activation of EGFR yielded less intense staining than the internal standards."
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"Knockdown of EGFR by siRNA ablated the inhibitory effect of SLO on cancer cell invasion, showing SLO selectively activated ErbB1 kinase to reduce invasion without increasing cell growth."
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"Independent experiments (n = 3) confirmed that 10 units/ml of recombinant SLO induced a significant (p < = 0.02) activation of EGFR in MDA-MB-231 cells compared to non treated control cells."
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