IndraLab

Statements

HCN4 binds cGMP. 2 / 2
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"Thus, binding of cGMP to the HCN4 channel may be relevant normally in vivo and reduced binding of cGMP, as well as cAMP, to the mutant channel may contribute to the reduced resting heart rate observed in the affected family."
35219649
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"A recent crystal structure of the cytosolic C-terminal fragment of HCN4 bound to cGMP allowed the discovery of a new interaction site [XREF_BIBR], located at the interface between the CNBD and the C-linker."
26975509