IndraLab

Statements

MIF activates COPS5. 7 / 8
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"Macrophage inhibitory factor (MIF), which has been reported to bind and hence inactivate Jab1, was also not changed in a direction which would explain the loss of nuclear p27 ( Pyle et al., 2003 )."
20347931
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"siRNA knockdown of CSN5 and JAB1, a tumor marker and MIF binding protein, showed that JAB1 controls autocrine MIF mediated Akt signaling by inhibition of MIF secretion."
17310986
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"Jab1 and CSN5 dependent stabilisation of HIF-1alpha is enhanced by MIF, leading to the subsequent activation of hypoxia responsive genes."
22955855
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"Interestingly, MIF was shown to modulate CSN5 function and subsequent CSN5 dependent effects on p27 degradation, JNK activation and AP-1-mediated transcription."
19186177
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"At low concentrations MIF induces the release of TNF-alpha, IL-12, IL-1beta, and PGE 2 and, in a distinct difference from other " common " cytokines, involves MAPK, Akt, and PI3K activation and regulation of Jab1 and p53 [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
22973314
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"The absence of MIF in females is associated with enhanced microglial activation and increased localization of JAB1 to the mitochondria in the infarcted brain."
23376686
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"MIF can modulate the activator protein-1 (AP-1) pathway and cell cycle progression through interaction with the coactivator and COP9 signalosome (CSN) component JAB1 and CSN5 [20]."
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