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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

Modified mutated TP53 decreases the amount of TP53. 3 / 3
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"The level of these small Hsps can also affect expression of mutant p53 protein which could reduce intracellular wild type p53 levels in cancer cells leading to reduction in apoptotic response."
"Overexpression of ectopic mutant p53 represses wild-type p53 stimulated transcription, known as a dominant negative effect."
"The loss or mutation of p53 in many cancers leads to impaired cell cycle regulation, genomic instability, and the inhibition of apoptosis The protein levels of p53 in the per1 silenced cells tended to be lower than those in the control cells, indicating that per1 regulated p53 expression, and this activity may at least partially contribute to the apoptosis of per1 silenced cells."