IndraLab

Statements

OTULIN binds RNF31 and PUB domain. 5 / 5
| 5
reach
"Although HOIP is able to interact with the AAA ATPase p97 and valosin containing protein (VCP) [XREF_BIBR, XREF_BIBR], which has recently been implicated in the recruitment of LUBAC to misfolded Huntingtin species [XREF_BIBR], the HOIP PUB domain binds OTULIN with a 40-fold higher affinity compared to p97 and VCP and NMR based in vitro studies indicate a more stable interaction between HOIP and OTULIN compared to p97 and VCP [XREF_BIBR]."
33288901
reach
"Both DUBs interact with the LUBAC complex - OTULIN directly binds the PUB domain of the catalytic subunit HOIP, which then recruits it to the TNFR complex."
38712244
reach
"Crystal structures and nuclear magnetic resonance experiments reveal the molecular basis for the high-affinity interaction and explain why OTULIN binds the HOIP PUB domain specifically."
24726323
reach
"Different from direct interaction between OTULIN and HOIP, CYLD binding to PUB domain of HOIP requires spermatogenesis-associated 2 (SPATA2) for bridge factor [23]."
37813853
reach
"OTULIN directly binds the PUB domain of HOIP to protect LUBAC from autoubiquitination, while CYLD associates with HOIP through Spermatogenesis-associated 2 (SPATA2) without affecting HOIP autoubiquiti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34157307