IndraLab
Statements
reach
"Although HOIP is able to interact with the AAA ATPase p97 and valosin containing protein (VCP) [XREF_BIBR, XREF_BIBR], which has recently been implicated in the recruitment of LUBAC to misfolded Huntingtin species [XREF_BIBR], the HOIP PUB domain binds OTULIN with a 40-fold higher affinity compared to p97 and VCP and NMR based in vitro studies indicate a more stable interaction between HOIP and OTULIN compared to p97 and VCP [XREF_BIBR]."