IndraLab

Statements

MTORC1 phosphorylates ASXL1. 30 / 30
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sparser
"MTORC1 phosphorylates S6 kinase, S6 ribosomal protein and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) which together increase protein translation and cell proliferation [ xref , xref - xref ]."
22001078
sparser
"MTORC1 phosphorylates p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), and regulates cell growth, proliferation, survival and motility."
21190521
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"While mTORC1 phosphorylates p70S6kinase (S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1) to increase protein synthesis, mTORC2 directly phosphorylates Akt, enhancing its kinase acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29408410
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"As we previously found, expression of wild-type UCH-L1 inhibits the mTORC1 phosphorylation of p70 S6 kinase (S6K) and the eIF4E binding protein 1 (4EBP1) and increases the phosphorylation of AKT S473 (Fig. xref a, b)."
31839994
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"Furthermore, mTORC1 positively regulates phosphorylation of S6K (at the Threonine 389 residue) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1), which together control protein translation ( xref )."
20421047
sparser
"MTORC1 phosphorylates two downstream targets, p70 S6K1 and eukaryotic initiation factor 4E binding protein 1 (4E-BP1), regulating protein translation, cell size, cell proliferation, and survival."
32968452
sparser
"Upon activation, mTORC1 directly phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1) to promote protein synthesis [ xref ]."
29375734
sparser
"When active, mTORC1 phosphorylates the translational regulators eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1)."
25092520
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"In addition, mTORC1 directly phosphorylates the eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1)."
25701355
sparser
"In addition, activated mTORC1 phosphorylates the eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) at Thr37/46, which prevents 4EBP1 from associating and thus repressing the eukary[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30262144
sparser
"MTORC1 phosphorylates p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), and regulates cell growth, proliferation, and survival by integrating hormones, growth factors, nutrients, stressors and energy signals."
20491627
sparser
"MTORC1 phosphorylates and activates the 70 kDa ribosomal S6 kinase (S6K1) and the translational repressor 4 elongation factor binding protein 1 (4E-BP1) [ xref , xref ] to promote cell growth and proliferation."
21128010
sparser
"MTORC1 directly phosphorylates the translational regulators eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1), which, in turn, promote protein synthesis (reviewed in ( xref ))."
22500797
sparser
"MTORC1 phosphorylates p70 S6 kinase (S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and regulates cell growth, proliferation, survival, and motility by integrating growth factors, nutrients, stressors, and energy signals[ xref , xref ]."
22059905
sparser
"Activated mTORC1 drives the phosphorylation of eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal p70 S6 kinase 1 (S6K1) ( Maiese et al., 2013 )."
29928901
sparser
"Once active, mTORC1 phosphorylates ribosomal protein S6 kinase (p70S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), promoting protein synthesis, including the translation of MYC and HIF1α ( xref )."
29049843
sparser
"For example, mammalian TORC1 directly phosphorylates translation initiation factor (eIF) 4E binding protein 1 (4E-BP1) to abolish its binding and inhibitory activity toward eIF-4E xref ."
18493323
sparser
"In its active form, mTORC1 phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1), which, consecutively, induce protein synthesis [ xref ]."
26997506
sparser
"MTORC1 phosphorylates and inhibits eukaryotic translation initiation factor 4E-binding protein 1 (4E‑BP1), an inhibitor of 5´cap-dependent translation."
27308421
sparser
"MTORC1 directly phosphorylates the two key translation regulators p70 ribosomal S6 kinase (P70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1)."
26097872
sparser
"MTORC1 phosphorylates p70 S6 kinase (S6K) and eukaryotic initiation factor 4E (elF4E) binding protein 1 (4E-BP1) and regulates cell growth, proliferation, survival, and motility by integrating growth factors, nutrients, stressors, and energy signals xref , xref ."
22059905
sparser
"MTORC1 phosphorylates eukaryotic initiation factor 4E-binding protein 1 (4EBP1) and p70-kDa S6 ribosomal protein kinase (p70S6K), promoting cap-dependent mRNA translation, ribosome biogenesis, and polysome assembly ( xref , xref )."
25724525
sparser
"In addition, activated mTORC1 phosphorylates the eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), which prevents 4EBP1 from associating with and thus repressing the eukaryotic translation initiation factor 4E (eIF4E) from recruiting the 40S ribosomal subunit to the 5′ end of mRNA ( xref )."
28634643
sparser
"The phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) by mTORC1 releases the eukaryotic translation initiation factor 4E (eIF4E) leading to cap-dependent mRNA translation."
28284028
sparser
"MTORC1 phosphorylates p70 ribosomal protein S6 kinase (p70 S6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1), which activates the ribosomal protein S6 (RPS6) and relieves eukaryotic initiation factor 4E (eIF4E), respectively."
28733220
sparser
"Subsequently, mTORC1 induces the phosphorylation of ribosomal protein S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1)."
28915718
sparser
"MTORC1 phosphorylates both the 70-kDa ribosomal S6 kinase (S6K1) and the translational repressor 4 elongation factor-binding protein 1 (4E-BP1) ( xref )."
22484804
sparser
"In particular, mTORC1 phosphorylates p70 S6 kinase (S6K) and eukaryotic initiation factor 4E binding protein 1 (4EBP1), thereby regulating translation of proteins that are critical for progression from G1 into S phase [ xref ]."
28238967
sparser
"When active, mTORC1 phosphorylates the translational regulator eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1), which, in turn, promote protein synthesis [ xref , xref ]."
24387336
sparser
"When active, mTORC1 phosphorylates eIF4E Binding Protein 1 (4E-BP1), thus rendering eIF4E free from 4E-BP1 inhibition, and thereby promotes cap-dependent initiation ( xref ; xref ; xref )."
34358439