IndraLab

Statements


Kinase-active JAK2 leads to the phosphorylation of STAT3. 2 / 2
2 |

"JAK2 associates with c-Kit and is phosphorylated after SCF stimulation (Brizzi et al., 1994b). JAK2 activation results in phosphorylation of STAT1?, 3, 5A and 5B"

"Growth arrest or OSM treatment also specifically increases activated (phosphorylated) signal transduction and activators of transcription 3 (STAT3) levels, demonstrating that STAT3, not STAT1 or STAT5, is the downstream target of the activated Janus kinases in MCF-10A"