IndraLab

Statements

KCNQ1 inhibits INS. 13 / 13
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"These data are consistent with the idea that increased KCNQ1 function impairs insulin secretion by inducing premature repolarization of the action membrane potential in pancreatic beta cells."
24843522
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"KCNE2 may regulate multiple K + channels in beta cells, including the T2DM linked KCNQ1 potassium channel alpha subunit.-Lee, S. M., Baik, J., Nguyen, D., Nguyen, V., Liu, S., Hu, Z., Abbott, G. W. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus."
28280005
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"It is also expressed in pancreatic islets, and blockade of the KvLQT1 channel stimulates insulin secretion in insulin secreting INS-1 cells XREF_BIBR."
20174558
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"In contrast, it was reported that an inhibitor of KCNQ1 (chromanol 293B) significantly increased insulin secretion in the presence of sulfonylurea; this finding suggested that the activity of KCNQ1 in subjects with the C allele of rs2237897, a risk allele for type 2 diabetes, might be higher than that in subjects with the T allele, a risk allele for diabetic nephropathy in the present study."
20056949
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"A Variant in the KCNQ1 Gene Predicts Future Type 2 Diabetes and Mediates Impaired Insulin Secretion."
19584308
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"In a physiological study in INS-1 cell cultures, the blockade of the KvLQT1 channel with KCNQ1 protein inhibitor 293B stimulated insulin secretion in the presence of sulphonylurea drug tolbutamide [XREF_BIBR], suggesting that KvLQT1 channels might play a role in fine tuning of insulin secretion during sulphonylurea treatment."
21709633
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"Inhibition of KCNQ1 in beta-cells increases insulin secretion."
24357532
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"In mice, Kcnq1 gene deletion causes deafness, loss of gastric acid secretion, altered insulin sensitivity, and hypothyroidism."
27098917
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"Loss of KCNQ1 expression may impair repolarisation of the beta cell and lead to failure to turn off insulin secretion."
26545876
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"Kcnq1 impairs insulin secretion by enhancing the beta-cell potassium currents."
28343791
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"Inhibition of KCNQ1 channel activity by the selective inhibitor chromanol 293B significantly increases insulin secretion in INS-1 cells XREF_BIBR, whereas KCNQ1 overexpression in MIN6 cells results in markedly impaired insulin secretion by glucose, pyruvate, or tolbutamide XREF_BIBR."
26678516
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"Mutation of CDKAL1, KCNQ1 or KCNJ11 Differentially Impairs Insulin Secretion in Response to Multiple Secretagogues."
27524441
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"Attenuation of KCNQ1 channel activity by the selective inhibitor chromanol 293B was found to enhance insulin secretion induced by tolbutamide in INS-1 cells."
24843522