IndraLab

Statements

USP10 activates cisplatin. 2 / 2
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"As we further tested the role of USP10 in cisplatin sensitivity in a large panel of NSCLC cell lines, surprisingly, we discovered that upon cisplatin treatment the depletion or inhibition of USP10 could lead to two entirely different outcomes: cell survival or apoptosis, depending on the cellular status of TP53—USP10 promotes cisplatin sensitivity in wild-type p53 cells, while USP10 confers cisplatin resistance in mutant p53 cells."
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"In addition, Spain-1, an inhibitor of USP10, inhibits melanoma growth and improves the anticancer effect of cisplatin by inhibiting USP10 activity [87,88]."
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