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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Syntaxin bound to KCNQ2 and 1A activates KCNQ2. 1 / 1

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"Here, we demonstrated that syntaxin 1A colocalizes with KCNQ2 subunits at hippocampal presynaptic boutons (XREF_FIG), binds to KCNQ2 in both synaptosomal membranes (XREF_FIG) and oocytes (XREF_FIG), and modulates the function of the homomeric KCNQ2 channels expressed in oocytes (XREF_FIG) by slowing the activation rate ~ 2 fold and decreasing the current amplitudes by about 50%; the latter is not due to reduced total expression or cell surface trafficking and stability of the channels (XREF_FIG)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...