IndraLab

Statements

ANGPTL2 increases the amount of CXCR4. 6 / 6
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"Angiopoietin-like protein 2, secreted by breast cancer cells, increases CXCR4 expression in breast cancer, which increases cross-talk between CXCR4 and CXCL12 and, as a result, recruits breast cancer cells to the bone metastatic site [146]."
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"In the present study, we performed RNA sequence analysis of MDA-MB231 cells harboring ANGPTL2 knockdown (MB231 and miANGPTL2) and found that, relative to control (MB231 and miLacZ) cells, CXCR4 expression significantly decreased, suggesting that ANGPTL2 contributes to CXCR4 expression in breast tumor cells."
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"In this study, we showed that ANGPTL2 significantly up-regulated CXCR4 expression in breast cancer cells, which likely enhances their responsiveness to CXCL12."
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"These results suggest that ANGPTL2 may enhance CXCR4 expression in breast cancer cells by increasing ETS1 expression."
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"We next examined the molecular basis for enhanced CXCR4 expression by ANGPTL2."
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"To investigate whether ANGPTL2 increases CXCR4 expression in other breast cancer cells, we generated T47-D lines that constitutively express ANGPTL2 (T47-D and ANGPTL2) and control vector-only lines (T47-D and Control) (XREF_SUPPLEMENTARY)."
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