IndraLab

Statements

SRC activates AKT1. 12 / 26
3 | 9
signor
"We also showed that phosphorylation of Tyr-315 in Akt induced by Src or EGF is dependent on the integrity of this proline-rich motif. Furthermore, the Akt mutant lacking this proline motif fails to block the transcription activity of Forkhead in 293 cells and poorly stimulates the proliferation of Madin-Darby canine kidney cells. Taken together, our data suggest that the interaction between the SH3 domain of Src family kinases and the proline-rich motif in the C-terminal regulatory region of Akt is required for tyrosine phosphorylation of Akt and its subsequent activation."
12600984
reach
"Phosphorylated IRS-1 will bind with regulatory subunit of phosphatidylinositol 3-kinase (PI3K) with Src homology 2 domain and further activate PI3K and protein kinase B (Akt)."
27656242
signor
"Regulation of Akt/PKB Activation by Tyrosine PhosphorylationAs shown in Fig. 2 d, while mutation of Tyr340 has little effect on either tyrosine phosphorylation or kinase activity of Akt induced by Src527F, substitution of Tyr315 or Tyr326 with a phenylalanine, respectively, dramatically reduces both the tyrosine phosphorylation and kinase activity of Akt. The combination of these two mutations abolishes Src-induced tyrosine phosphorylation of Akt as well as its kinase activity."
11445557
reach
"Park et al. 29 reported that AKT1 is transcriptionally upregulated by the SRC and STAT3 pathway through direct binding of STAT3 on the AKT1 promoter 29."
25987255
reach
"The complexation between transmembrane molecules, integrins, and extracellular matrix (ECM) initiates the survival cascade via stimulation of FAK and Src (Proto-oncogene tyrosine protein kinase) consequently activating the downstream PI3K (phosphoinositide 3-kinase)/Akt (Protein kinase B) signaling pathway 18."
33603033
reach
"In basal keratinocytes, alpha3beta1 and laminin (LN) -332 drives FAK and Src activation, whereas in suprabasal layers, junctional alpha3beta1 and the tetraspanin CD151 mediate signal transducer and protein kinase B (Akt)-dependent survival that is independent of LN-332 binding."
33752808
reach
"The induction of such a migratory phenotype is mediated by AKT and SRC pathways as well as RAC induced cytoskeleton changes [XREF_BIBR, XREF_BIBR]."
28251492
reach
"For example, the phosphorylation of Y315 AKT1 (204 PKA), as well as Y326 AKT1 (215 PKA), is necessary for the activation of AKT1 by Src XREF_BIBR - XREF_BIBR."
27731453
reach
"Src mediates protein kinase B, also known as Akt, a key factor in the regulation of cancer cell survival in the bone metastasis microenvironment."
28824875
reach
"SRC also stimulates and increases AKT1 activity."
30949321
signor
"Regulation of Akt/PKB Activation by Tyrosine PhosphorylationAs shown in Fig. 2 d, while mutation of Tyr340 has little effect on either tyrosine phosphorylation or kinase activity of Akt induced by Src527F, substitution of Tyr315 or Tyr326 with a phenylalanine, respectively, dramatically reduces both the tyrosine phosphorylation and kinase activity of Akt. The combination of these two mutations abolishes Src-induced tyrosine phosphorylation of Akt as well as its kinase activity."
11445557
reach
"Since ILK is not capable of direct phosphorylation of Akt1 as a pseudokinase [47] and FAK and c-Src and Akt1 can regulate each other [48-50], CD98 activated FAK and c-Src can induce Akt1 activation."
26172215