IndraLab

Statements

OTUB1 inhibits UBE2N. 25 / 30
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reach
"OTUB1 strongly suppresses UBC13 dependent Lys-63-linked tri-Ub production, whereas it allows di-Ub production in vitro."
22679021
eidos
"OTUB1 inhibits UBE2N by binding to the charged E2 ~ Ub thioester intermediate and preventing ubiquitin transfer ( 17 , 19 , 20 ) ."
30282802
sparser
"OTUB1 directly inhibits the E2 enzyme UBC13, independently of its catalytic activity."
31164001
reach
"It was reported that Otub1, a deubiquitinase, also negatively regulates the DDR in a catalytically independent manner by regulating the activity of UBC13, an E2 ubiquitin conjugating enzyme for RNF8."
29167269
sparser
"Here we describe structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes."
22367539
sparser
"Our rationale was to test whether OTUB1 can inhibit yeast Ubc13."
22325355
reach
"Surprisingly, UBC13, which is inhibited by OTUB1, did not stimulate OTUB1 as strongly as the other activating E2s."
23955022
reach
"Here we describe structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes."
22367539
sparser
"In this study, we sought to elucidate the structural mechanism by which OTUB1 recognizes and inhibits UBC13, UbcH5 and related E2 enzymes."
22325355
reach
"Our rationale was to test whether OTUB1 can inhibit yeast Ubc13."
22325355
reach
"OTUB1 inhibits UBE2N by binding to the charged E2∼Ub thioester intermediate and preventing ubiquitin transfer (17, 19, 20)."
30282802
signor
"The deubiquitinating enzyme otub1 suppresses rnf168 dependent ubiquitination by direct the e2 ligase ubc13"
21763684
reach
"Consistent with a functional importance of this pocket, the F190S mutation disrupted the ability of OTUB1 to suppress UBC13 activity in vitro (XREF_FIG)."
22325355
sparser
"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [ xref , xref ]."
25833379
sparser
"Another DUB, OTUB1, directly binds and inhibits the E2 Ubc13 by a mechanism independent of its catalytic isopeptidase activity [ xref ]."
21549706
reach
"Although human ovarian tumor domain containing ubiquitin aldehyde binding protein 1 (OTUB1) was previously identified as a K48 linkage specific deubiquitinating enzyme that positively regulates p53 stability 22, OTUB1 strongly suppresses E2-ubiquitin-conjugating enzyme UBC13 dependent K63 linked ubiquitination XREF_BIBR, XREF_BIBR."
28776570
reach
"It is worth noting that OTUB1 inhibits UBE2D/2E family in in vitro experiments as well as UBC13, indicating that deubiquitylating activity independent regulation of E2 might be a common mechanism for [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28764946
sparser
"OTUB1 inhibits UBE2N by binding to the charged E2∼Ub thioester intermediate and preventing ubiquitin transfer ( xref , xref , xref )."
30282802
sparser
"Intriguingly, OTUB1 inhibits UBC13 and UBE2D/2E-family E2 conjugating enzymes in a DUB activity-independent manner [ xref ]."
26983989
reach
"A20 and OTUB1 disrupt Ubc13/UBE2N signaling by assembling complexes that can deubiquitinate and induce proteolysis of both K48 and K63 linked polymers."
34965427
reach
"Other cellular regulators of Ubc13/UBE2N have been described, notably the OTUB family proteins, A20 (TNFΑIP3) and OTUB1, which can inactivate Ubc13/UBE2N signaling to NF-κB from TRAF, TLR, IL-1β, TNFα, and DNA repair pathways (Nakada et al., 2010; Shembade and Harhaj, 2010; Shembade et al., 2010)."
34965427
reach
"Intriguingly, the functional active site of OTUB1 is not required to inhibit Ubc13."
23896398
reach
"Intriguingly, OTUB1 inhibits UBC13 and UBE2D/2E family E2 conjugating enzymes in a DUB activity independent manner [XREF_BIBR]."
26983989
reach
"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [XREF_BIBR, XREF_BIBR]."
25833379
sparser
"Surprisingly, UBC13, which is inhibited by OTUB1, did not stimulate OTUB1 as strongly as the other activating E2s."
23955022