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OTUB1 inhibits UBE2N. 32 / 37
1 | 1 17 13
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"Intriguingly, the functional active site of OTUB1 is not required to inhibit Ubc13."
23896398
sparser
"OTUB1 inhibits UBC13 (also known as UBE2N) and other E2 enzymes."
25444757
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"OTUB1 inhibits UBC13 (also known as UBE2N) and other E2 enzymes."
25444757
reach
"OTUB1 directly inhibits the E2 enzyme UBC13, independently of its catalytic activity."
31164001
reach
"Although human ovarian tumor domain containing ubiquitin aldehyde binding protein 1 (OTUB1) was previously identified as a K48 linkage specific deubiquitinating enzyme that positively regulates p53 stability 22, OTUB1 strongly suppresses E2-ubiquitin-conjugating enzyme UBC13 dependent K63 linked ubiquitination XREF_BIBR, XREF_BIBR."
28776570
reach
"Other cellular regulators of Ubc13/UBE2N have been described, notably the OTUB family proteins, A20 (TNFΑIP3) and OTUB1, which can inactivate Ubc13/UBE2N signaling to NF-κB from TRAF, TLR, IL-1β, TNFα, and DNA repair pathways (Nakada et al., 2010; Shembade and Harhaj, 2010; Shembade et al., 2010)."
34965427
reach
"A20 and OTUB1 disrupt Ubc13/UBE2N signaling by assembling complexes that can deubiquitinate and induce proteolysis of both K48 and K63 linked polymers."
34965427
sparser
"Surprisingly, UBC13, which is inhibited by OTUB1, did not stimulate OTUB1 as strongly as the other activating E2s."
23955022
reach
"Our rationale was to test whether OTUB1 can inhibit yeast Ubc13."
22325355
reach
"Consistent with a functional importance of this pocket, the F190S mutation disrupted the ability of OTUB1 to suppress UBC13 activity in vitro (XREF_FIG)."
22325355
sparser
"In DNA double-strand break (DSB) repair, OTUB1 and OTUB2 act as negative modulators of DSB-induced ubiquitination through distinct mechanisms: OTUB1 inhibits UBC13 in an enzyme-independent manner to suppress RNF168-dependent polyubiquitination, xref whereas OTUB2 inhibits RNF8-mediated ubiquitination of L3MBTL1 and K63-linked ubiquitin chain formation, to support appropriate DNA repair pathway choice. xref "
41550777
sparser
"Intriguingly, OTUB1 inhibits UBC13 and UBE2D/2E-family E2 conjugating enzymes in a DUB activity-independent manner [ xref ]."
26983989
sparser
"In contrast to HERC2, OTUB1 binds to and inhibits UBC13 and thereby suppresses RNF168-dependent polyubiquitination [53] ."
21570976
sparser
"In this study, we sought to elucidate the structural mechanism by which OTUB1 recognizes and inhibits UBC13, UbcH5 and related E2 enzymes."
22325355
sparser
"OTUB1 inhibits UBE2N by binding to the charged E2∼Ub thioester intermediate and preventing ubiquitin transfer ( xref , xref , xref )."
30282802
sparser
"Our rationale was to test whether OTUB1 can inhibit yeast Ubc13."
22325355
sparser
"Although our findings thus far support our model of ehOTUB1 sterically clashing with Ub(A) to inhibit UBE2K, it is known that inhibition of UBE2N–UBE2V1 by human OTUB1 is potentiated by binding of ubiquitin to the human OTUB1 active site xref , xref ."
40766534
sparser
"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [ xref , xref ]."
25833379
sparser
"OTUB1 directly inhibits the E2 enzyme UBC13, independently of its catalytic activity."
31164001
reach
"OTUB1 inhibits the RNF168 E2 enzyme UBE2N (and probably also other E2s) independently of its de-ubiquitylating activity [XREF_BIBR, XREF_BIBR]."
25833379
reach
"It was reported that Otub1, a deubiquitinase, also negatively regulates the DDR in a catalytically independent manner by regulating the activity of UBC13, an E2 ubiquitin conjugating enzyme for RNF8."
29167269
reach
"OTUB1 inhibits the E2 enzyme, Ubc13/UBE2N plus other E2 conjugating enzymes, independently of its DUB activity by binding directly to the charged E2∼Ub via an N-terminal extension that contains a Ub-binding motif [104,105]."
38572758
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"OTUB1 strongly suppresses UBC13 dependent Lys-63-linked tri-Ub production, whereas it allows di-Ub production in vitro."
22679021
reach
"OTUB1 inhibits UBE2N by binding to the charged E2∼Ub thioester intermediate and preventing ubiquitin transfer (17, 19, 20)."
30282802
reach
"Surprisingly, UBC13, which is inhibited by OTUB1, did not stimulate OTUB1 as strongly as the other activating E2s."
23955022
signor
"The deubiquitinating enzyme otub1 suppresses rnf168 dependent ubiquitination by direct the e2 ligase ubc13"
21763684
reach
"It is worth noting that OTUB1 inhibits UBE2D/2E family in in vitro experiments as well as UBC13, indicating that deubiquitylating activity independent regulation of E2 might be a common mechanism for [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28764946
reach
"Here we describe structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes."
22367539
sparser
"Another DUB, OTUB1, directly binds and inhibits the E2 Ubc13 by a mechanism independent of its catalytic isopeptidase activity [ xref ]."
21549706
sparser
"Here we describe structural and biochemical studies elucidating how OTUB1 inhibits UBC13 and other E2 enzymes."
22367539
eidos
"OTUB1 inhibits UBE2N by binding to the charged E2 ~ Ub thioester intermediate and preventing ubiquitin transfer ( 17 , 19 , 20 ) ."
30282802
reach
"Intriguingly, OTUB1 inhibits UBC13 and UBE2D/2E family E2 conjugating enzymes in a DUB activity independent manner [XREF_BIBR]."
26983989