IndraLab

Statements


KCNMA1 activates ESRRB. 7 / 7
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"Besides, hBMSCs showed significantly increased efficiency in SOX9 expression level in both CPP- and SLO mediated ESRRB delivered cells, but significantly higher expression was detected in CPP-ESRRB delivered cells than SLO mediated ESRRB delivered cells (XREF_FIG)."

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"In case of chondrogenic differentiation, COMP and SOX9 were used as chondrogenesis specific markers, and CPP-ESRRB delivered hTSCs showed much higher expression level in COMP compares to control and SLO mediated ESRRB delivered cells."

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"In addition, to measure biological activity of ESRRB in other way, proliferation rate of control, CPP conjugated and SLO mediated ESRRB delivered hTSCs and hBMSCs were calculated."

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"Finally, to compare the biological activity of CPP-ESRRB and SLO mediated ESRRB delivery, hTSCs and hBMSCs were treated, and the cells were collected 24hr after delivery."

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"Additionally, cellular uptake of the CPP-ESRRB protein was more efficient than that of the SLO mediated ESRRB protein (XREF_FIG)."

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"CPP conjugated ESRRB delivery presented a more efficient uptake and a more significant increase in the expression levels of OCT4, SOX2 and NANOG than SLO mediated ESRRB delivery."

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"In adipogenic differentiation, we confirmed elevated expression level of C/EBPalpha and PPARgamma which are adipogenic specific markers in both CPP conjugated and SLO mediated ESRRB delivered cells compare to control cells."