IndraLab

Statements


CBL decreases the amount of EGFR. 6 / 16
1 | 6

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"The ectopic expression of c-Cbl decreased EGFR expression and inhibited the growth of NSCLC [56]."

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"c‐Cbl overexpression decreased EGFR protein levels in liver cancer cells (Supplementary Figure S7B)."

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"We show that silencing Cdc42 significantly reduces protein levels of EGFR, leading to a marked reduction in cell proliferation and migration, and c-Cbl knockdown increases the levels of EGFR."

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"C-Cbl served as an internal control and significantly reduced the total amount of EGFR as previously shown [38]."

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"Increasing evidences show that Cbl negatively regulate the expression of EGFR [XREF_BIBR], therefore, immunolabeling for EGFR was performed on the entire cohort 1 in an effort to determine if the prognostic value of Cbl density was related to EGFR status."

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"Proteasomal degradation of Cbl was promoted through its tyrosine phosphorylation and polyubiquitination, resulting in increased EGFR expression."