IndraLab

Statements

CBL decreases the amount of EGFR. 4 / 13
1 | 3
reach
"Increasing evidences show that Cbl negatively regulate the expression of EGFR [XREF_BIBR], therefore, immunolabeling for EGFR was performed on the entire cohort 1 in an effort to determine if the prognostic value of Cbl density was related to EGFR status."
26474280
reach
"We show that silencing Cdc42 significantly reduces protein levels of EGFR, leading to a marked reduction in cell proliferation and migration, and c-Cbl knockdown increases the levels of EGFR."
16585176
reach
"C-Cbl served as an internal control and significantly reduced the total amount of EGFR as previously shown [38]."
18602463
signor
"Ligand binding to EGFR also leads to rapid internalization and proteosomal/lysosomal degradation of the receptors. This process results in a dramatic downregulation of both total and cell surface receptors. EGF-induced degradation of EGFR is thought to be initiated by phosphorylation of tyrosine 1045 of the receptor followed by binding of Cbl adaptor proteins and ubiquitination of the receptor. Internalized EGFR is transported to early endosomes where receptor-ligand complexes are sorted for either degradation or recycling to the cell surface."
20332299