IndraLab

Statements

USP9X activates CTNNB1. 8 / 13
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"At molecular level , USP9X induces beta-catenin signaling to mediate HCC progression.124 Therefore , mediating GSK-3beta degradation and triggering beta-catenin nuclear translocation can significantly enhance proliferation rate of HCC cells.125 Besides , activation of beta-catenin signaling induces resistance of HCC cells toward apoptosis.126 Histone deacetylase 6 ( HDAC6 ) acts as tumor-suppressor and diminishes beta-catenin expression to induce apoptosis in HCC cells ."
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"By evaluating signaling in U251 cells treated with a Wnt ligand, we found that USP9X knockdown partly blocked the activation of Wnt and beta- catenin pathway by regulating the stability of beta-catenin."
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"Down-regulation of USP9X also consistently inhibits the tumorigenicity of primary glioma cells in vivo.In summary, these results indicate that USP9X stabilizes beta-catenin and activates Wnt and beta-catenin signal pathway to promote glioma cell proliferation and survival."
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"In summary, these results indicate that USP9X stabilizes beta-catenin and activates Wnt and beta-catenin signal pathway to promote glioma cell proliferation and survival."
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"The results of the western blot suggested that knockdown of USP9X decreased beta-catenin protein, but the results of RT-PCR suggested that beta-catenin mRNA expression levels did not change (XREF_SUPPLEMENTARY)."
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"Previous studies have suggested that USP9X is co-immunoprecipitated with beta-catenin and inhibits the degradation of beta-catenin through the deubiquitination of beta-catenin in mouse lymphocyte cells [XREF_BIBR]."
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"USP9X promotes the progression of hepatocellular carcinoma by regulating beta-catenin."
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"At molecular level, USP9X induces β-catenin signaling to mediate HCC progression.124 Therefore, mediating GSK-3β degradation and triggering β-catenin nuclear translocation can significantly enhance proliferation rate of HCC cells.125 Besides, activation of β-catenin signaling induces resistance of HCC cells toward apoptosis.126 Histone deacetylase 6 (HDAC6) acts as tumor-suppressor and diminishes β-catenin expression to induce apoptosis in HCC cells."
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