IndraLab

Statements

SPATA2 binds CYLD and PUB domain. 4 / 4
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"It has been shown that the USP domain of CYLD binds the PUB domain of spermatogenesis associated protein 2 (Spata2), leading to recruitment of CYLD to the centrosome and de-ubiquitination of Plk4."
33777739
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"SPATA2 interacts with CYLD through its non canonical PUB domain, which binds the catalytic CYLD USP domain in a CYLD B-box-dependent manner."
27591049
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"The strongest effect on CYLD binding was observed when we mutated Tyr114, which points away from the PIM pocket (XREF_FIG E and 2G), supporting that CYLD binds the SPATA2 PUB domain in a PIM independent manner."
27591049
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"SPATA2 binds the USP domain of CYLD via its PUB domain, but in a PIM independent manner."
27591049