IndraLab

Statements

USP5 increases the amount of mebendazole. 4 / 4
| 4
reach
"Notably, we found that USP5 mRNA expression was also decreased by mebendazole, suggesting that mebendazole might suppress USP5 transcription."
31197245
reach
"The mechanistic investigation showed that mebendazole not only prevents the interaction between USP5 and c-Maf but also suppresses USP5 transcription, thus inducing c-Maf proteasomal degradation.Notably, mebendazole is cytotoxic to various cancer cells, including MM and leukemia cells, at higher concentrations (data not shown); however, it elicits selective anti-MM activity at low concentrations."
31197245
reach
"Notably, we found that USP5 mRNA expression was also decreased by mebendazole, suggesting that mebendazole might suppress USP5 transcription.Because c-Maf turnover is processed via the proteasome, we sought to determine whether mebendazole induced c-Maf Fig. 2 Mebendazole inhibits USP5 expression and induces c-Maf degradation via the ubiquitin-proteasome pathway."
31197245
reach
"The mechanistic investigation showed that mebendazole not only prevents the interaction between USP5 and c-Maf but also suppresses USP5 transcription, thus inducing c-Maf proteasomal degradation."
31197245