IndraLab
Statements
CYLD activates signal transduction. 3 / 3
|
3
reach
"Treatment of MEFs with either 12-O-tetradecanoylphorbol-13 acetate (TPA) (XREF_FIG) or TNF-alpha (XREF_FIG) which was shown earlier to regulate CYLD mediated signal transduction XREF_BIBR, XREF_BIBR, were unable to increase the proliferation rate of CYLD-/- MEFs compared to CYLD +/+ over a period of 24-96 hours (XREF_FIG)."
reach
"A proposed model explaining how p62 mutations lead to the Paget's disease of bone is the following: mutations of the UBA domain cause an impairment in the interaction between p62 and ubiquitinated TRAF6 and/or CYLD, an enzyme deubiquitinating TRAF6, which in turn enhances the activation of the NF-κB signaling pathway and the resulting increased osteoclastogenesis (Figure 3(b)) [160]."