IndraLab

Statements

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"After 8 days of treatment with all-trans-retinoic acid (ATRA) on the NB SK-N-BE 2) C cell line, the SUMOization of CYLD decreased, while its expression increased, which blocked the NF-κB signal transduction pathway and promoted cell death (Kobayashi et al., 2015)."
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"miR-130b regulated NF-κB signaling pathway mediated by Cyld."
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"These data suggest that accumulation of Optn/CYLD in the nucleus during the G2/M transition leads to enhancement of TBK1 activity, IFN and ISG expression and thus promotes activation of the antiviral [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD can also modulate the NF-κB signaling pathway, which plays a crucial role in the inflammatory response and osteoclast mediation in periodontitis (34).2.3 Roles of USPs in pneumonia."
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"So we speculate that alterations in FAT4, SMARCA4, CYLD, CTNNB1, and KIT, which activate Wnt/β-catenin signaling pathway, may also be the potential predictive factors for the development of HPD.HPD is a novel pattern of progression characterized by an unexpected rapid acceleration of tumor growth, occurring in a subset of patients after initial ICI treatment."
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"This post-translational modification inhibits CYLD’s deubiquitination activity toward TRAF2 and TRAF6, activating the NF-κB signaling pathway."
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"miR-135b binds to the 3' untranslated region (UTR) of the Cylindromatosis (CYLD) gene mutation, activating the NF-κB signaling pathway."
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"VPO1 exacerbates cardiomyocyte programmed necrosis in CHF rats by upregulating CYLD, which activates the RIPK1/RIPK3/MLKL signaling pathway."
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"26 In our previous study, we demonstrated that neuronal CYLD could suppress microglial activation by negatively regulating the NF-κB signaling pathway after focal cerebral ischemia/reperfusion."
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"CYLD deficiency impairs the DNA-triggered signaling pathway."
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"Treatment of MEFs with either 12-O-tetradecanoylphorbol-13 acetate (TPA) (XREF_FIG) or TNF-alpha (XREF_FIG) which was shown earlier to regulate CYLD mediated signal transduction XREF_BIBR, XREF_BIBR, were unable to increase the proliferation rate of CYLD-/- MEFs compared to CYLD +/+ over a period of 24-96 hours (XREF_FIG)."
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"CYLD could enhance apoptosis through negatively regulating NF-κB signaling pathway."
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"Mechanically, CYLD, through deubiquitination, is able to remove the Ub chain on TRAF6 and inactivate it, thereby inhibiting the activation of the RANK signaling pathway (76)."
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