IndraLab

Statements

BAP1 inhibits BRCA1. 14 / 18
| 14
reach
"BAP1 enhances BRCA1 mediated suppression of cell growth in colony formation assays, and this suppression by BAP1 is augmented by its UCH enzymatic domain."
10546591
reach
"BAP1 enhances BRCA1 mediated inhibition of breast cancer cell growth and is the first nuclear localized ubiquitin carboxy-terminal hydrolase to be identified."
9528852
reach
"In our study, we found that BAP1 depletion decreased the assembly of constitutive BRCA1 foci, which are associated with HR, but had minimal effect on gamma-H2AX foci."
29113987
reach
"Biochemical studies revealed that BARD1 potentiates the ubiquitin ligase activity of BRCA1, which can be reversed through the inhibition of BRCA1-BARD1 association by BRCA1 associated protein 1 (BAP1) 64."
20029420
reach
"A previous study on the expression of BAP1 tumor suppressor gene in 1222 patients with TCGA breast cancer data reported that the expression of BAP1, which enhances BRCA1-mediated suppression of cell proliferation through BRCA1 stabilization, is highly correlated with USP19 expression."
| PMC
reach
"XREF_BIBR suggested that BAP1 inhibits the E3 ligase activity of BRCA1 in a manner independent of its deubiquitination activity."
26011428
reach
"XREF_BIBR It was initially suggested that BAP1 bound BRCA1 cleaves ubiquitin, and enhances the growth-suppressive effects of BRCA1."
24855403
reach
"We further found that BAP1 depletion suppressed the assembly of constitutive BRCA1 foci, which are associated with homologous recombination (HR), but had minimal effect on gamma-H2AX foci and did not affect proteins associated with nonhomologous end joining, suggesting that BAP1 affects radiosensitivity in HNSCC by modifying HR."
29113987
reach
"Early experiments found that BAP1 enhanced BRCA1 mediated inhibition of breast cancer cell growth."
25521456
reach
"BAP1 enhances BRCA1 mediated suppression of cell proliferation through stabilizing BRCA1 [XREF_BIBR]."
30716094
reach
"The downregulation of BAP1 expression by BCR-ABL reduces the stability of BRCA1 in chronic myeloid leukemia."
26118501
reach
"Furthermore, the two proteins appeared to interact in a biologically significant manner because BAP1 augmented the growth suppressive properties of BRCA1 in breast cancer cells."
18687060
reach
"We further found that BAP1 depletion suppressed the assembly of constitutive BRCA1 foci, which are associated with homologous recombination (HR), but had minimal effect on gamma-H2AX foci and did not affect proteins associated with nonhomologous end joining, suggesting that BAP1 affects radiosensitivity in HNSCC by modifying homologous recombination."
29113987
reach
"XREF_BIBR previously suggested that BAP1 enhanced BRCA1 mediated inhibition of cancer cell growth, although they did not directly establish the possibility that BAP1 enhances the BRCA1 protein level."
26011428