IndraLab

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HEY1 increases the amount of PSMD14. 6 / 6
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"It was observed from wound healing and Transwell assays that HEY1 knockdown significantly decreased the migratory and invasive capabilities of PSMD14-overexpressing trophoblasts compared with those in PSMD14-overexpressing cells transfected with sh-NC (Fig. 5A-D)."
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"Further in vivo and clinical studies are required to verify the findings in the present study.In conclusion, the present study demonstrated that HEY1 can activate PSMD14 expression, thereby promoting trophoblast proliferation, invasion and migration, in addition to downstream endothelial angiogenesis."
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"Furthermore, the transcription factor HEY1 activated the expression of PSMD14."
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"Transcription factor HEY1 activates PSMD14 expression."
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"Collectively, these results suggest that the transcription factor HEY1 can activate PSMD14 expression in HTR-8/SVneo trophoblast cells."
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"HEY1 silencing reverses the positive effects of PSMD14 overexpression on trophoblast proliferation."
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