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DNMT3B methylates TP53. 5 / 5
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"In conclusion, our data strongly illuminates that ROS-PI3K and Akt pathway participates in the PM2.5-induced DNMT3B up-regulation, which leads to P53 promoter hypermethylation and down-regulation of P53 expression, a critical early event in epithelial cell carcinogenesis."
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"On the other hand P53 also has been related with DNMT3b, since it has been identified that the hypermethylation of p53 promoter by DNMT3b causes a decrease of its expression level and promotes an increase of cell proliferation [XREF_BIBR]."
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"MSPs of p53 and p21 were performed and revealed that silencing of DNMT3B decreased methylation of p53 and p21, respectively (XREF_FIG C and 5D)."
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"These findings provide further evidence that DNMT3B mediates PM2.5-induced hypermethylation of P53 promoter."
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"XREF_BIBR, XREF_BIBR Furthermore, note that silencing of DNMT3B decreased methylation of p53 and p21, respectively."
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