IndraLab

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Aldosterone increases the amount of KCNMA1. 6 / 6
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"In addition to its more prominent role in the regulation of Na absorption, aldosterone is also known to induce active K secretion by enhancing BK channel expression in the distal colon."
33908679
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"Using the model of secondary hyperaldosteronism induced by dietary Na depletion in rats, or using exogenous aldosterone applied directly to ex vivo tissues, we provide novel evidence that aldosterone upregulates NKCC1 and BK channel expression in a coordinated manner to facilitate active K secretion, without concurrently enhancing Cl secretion in the distal colon."
33908679
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"These observations strongly suggest that aldosterone induced active K secretion by regulating both IK and KCNMA1α expression at the transcriptional level (176)."
30215859
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"Aldosterone directly enhances BK channel activity and may possibly increase BK channel expression in colonic crypts [15] but not in cortical collecting duct cells [16] ."
19070588
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"Some investigators have reported that aldosterone stimulates the expression of BK channel subunits in the apical membranes of beta intercalated cells, although dietary Na + restriction was not found to increase flow stimulated K + secretion in rabbits."
24402096
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"In addition to the increase in ENath channel activity, aldosterone also augments the increase in renal outer medullary Kth channel density (Palmer et al. 1994) and increases BK channel expression and activity in the colon (Sorensen et al. 2008)."
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