IndraLab

Statements

Aldosterone increases the amount of KCNMA1. 4 / 4
| 4
reach
"Using the model of secondary hyperaldosteronism induced by dietary Na depletion in rats, or using exogenous aldosterone applied directly to ex vivo tissues, we provide novel evidence that aldosterone upregulates NKCC1 and BK channel expression in a coordinated manner to facilitate active K secretion, without concurrently enhancing Cl secretion in the distal colon."
33908679
reach
"In addition to its more prominent role in the regulation of Na absorption, aldosterone is also known to induce active K secretion by enhancing BK channel expression in the distal colon."
33908679
reach
"These observations strongly suggest that aldosterone induced active K secretion by regulating both IK and KCNMA1α expression at the transcriptional level (176)."
30215859
reach
"Some investigators have reported that aldosterone stimulates the expression of BK channel subunits in the apical membranes of beta intercalated cells, although dietary Na + restriction was not found to increase flow stimulated K + secretion in rabbits."
24402096