IndraLab

Statements

TSC2 is degraded. 7 / 7
| 5 2
trips
"Binding with HPV16 E6 causes the proteasome-mediated degradation of Tuberin."
15175323
reach
"In addition, SCs transfected with the miR-1764 agomir led to an improvement of proliferation capacity through down-regulating AMPKα2 level, which further decreased TSC2 expression and induced mTOR activation."
34481229
trips
"Taken together, degradation of TSC2 is mediated by E6AP ubiquitin ligase."
18298802
trips
"FBXW5 is a TSC2 binding receptor within CUL4 E3 ligase complex, and it promotes proteasomal degradation of TSC2."
24372178
reach
"DP effectively inhibited the phosphorylation of PI3K and its downstream factors p-Akt and p-mTOR, oppositely enhanced the expression of TSC1 (hamartin) and TSC2 (tuberin), which could be reversed by the co-treatment with the PI3K inhibitor wortmannin."
26239613
trips
"In the present study, we investigated the role of E6-associated protein (E6AP) in HPV16 E6-induced TSC2 degradation."
18298802
trips
"We previously found that HPV16 E6 causes the degradation of the tumor suppressor protein TSC2, resulting in the phosphorylation of S6 kinase and S6 even in the absence of insulin."
18298802