IndraLab

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MDM2-T309G increases the amount of MDM2. 2 / 4
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"XREF_BIBR, XREF_BIBR, XREF_BIBR With this CRISPR and Cas9 technology, we have created the MDM2 T309G in the genomic DNA of human primary RPE (hRPE) cells and found that the MDM2 T309G mutation enhances rabbit vitreous (RV)-induced expression of MDM2 and cell proliferation, 21 but whether this mutation contributes to the pathogenesis of PVR is still unclear."
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"However, dCas9/ MDM2 -sgRNA-directed genetic silencing of P2-driven aberrant MDM2 expression (by which MDM2 T309G functions to elevate MDM2 level) significantly diminishes PVR vitreous-induced biologi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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