IndraLab

Statements

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"For instance, while loss of Bap1 activates intrinsic apoptosis in several mouse cell types (hepatocytes, keratinocytes, fibroblasts, and embryonic stem cells) in an RNF2 dependent fashion, the Bap1 loss enhances proliferation of melanocytes in association with upregulation of lineage specific oncogenes MITF and BCL2, independently of RNF2."
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"Thus , loss of BAP1 activity prevents Bcl2 and Mcl1 expression and triggers apoptosis ."
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"Since both BAP1 and PTEN inhibit apoptosis in a similar way, increasing the likelihood for pre-malignant cells to survive, it is tempting to speculate that also PTEN mutations may contribute to mesothelioma development in carriers of PTEN mutations, as demonstrated in animal models carrying germline BAP1 mutations with even minimal exposure to asbestos [30]."
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"The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death."
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"In RCC cells, BAP1 inhibited glucose deprivation-induced apoptosis through interaction with the activating transcription factor 3 (ATF3) and DNA damage-inducible transcript 3 protein (DDIT3) gene promoters in a polycomb complex protein BMI-1-dependent manner ."
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