IndraLab

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"2 Specific genes have also been implicated, in particular the tumor suppressor gene BAP1 , which promotes apoptosis through binding, deubiquitylating, and stabilizing calcium release into the cytosol [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mito-TEMPO pretreatment inhibited ODN-induced BAP1 phosphorylation, increased Bax expression, and promoted apoptosis induced by the combined treatment of ODN and oxaliplatin (Fig. 9, Fig. 10E).5 Conclusion."
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"BAP1 depletion increases apoptosis in colon cancer cells."
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"Consistent with identification of BAP1 in CRISPR/Cas9 screens for fitness genes (17) and evidence that BAP1 loss promotes apoptosis on many cell backgrounds (18), our data suggest that complete deletion of BAP1 may be incompatible with MeT5A cell survival."
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"Moreover, the tumor suppressor BRCA1-associated protein 1 (BAP1) which localizes at the ER, promotes ER-mitochondrial Ca 2+ transfer and induces apoptosis by stabilizing IP3R3."
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"In RCC cells, BAP1 inhibited glucose deprivation-induced apoptosis through interaction with the activating transcription factor 3 (ATF3) and DNA damage-inducible transcript 3 protein (DDIT3) gene promoters in a polycomb complex protein BMI-1-dependent manner ."
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"The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death."
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"The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death."
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"49 Moreover, BAP1 induces apoptosis by binding to the 14‐3‐3 protein or suppresses apoptosis by stabilizing liver kinase B1 (LKB1)."
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"In vitro , overexpression of BAP1 reduced the LPS-induced injury and apoptosis in the RTECs."
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"Thus , loss of BAP1 activity prevents Bcl2 and Mcl1 expression and triggers apoptosis ."
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"Since both BAP1 and PTEN inhibit apoptosis in a similar way, increasing the likelihood for pre-malignant cells to survive, it is tempting to speculate that also PTEN mutations may contribute to mesothelioma development in carriers of PTEN mutations, as demonstrated in animal models carrying germline BAP1 mutations with even minimal exposure to asbestos [30]."
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"For instance, while loss of Bap1 activates intrinsic apoptosis in several mouse cell types (hepatocytes, keratinocytes, fibroblasts, and embryonic stem cells) in an RNF2 dependent fashion, the Bap1 loss enhances proliferation of melanocytes in association with upregulation of lineage specific oncogenes MITF and BCL2, independently of RNF2."
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"BAP1 depletion increased apoptosis in HCT116, HT29, SW48, SW480, RKO and DLD-1 cells, with little effect on HCT15 and LoVo cells (Fig. 3)."
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