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CDK4 phosphorylates RB1 on S608. 3 / 3
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"This study shows that Ser-608 in pRb was phosphorylated in vitro by Cdk4 and Cdk6."

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"We then directly examined Rb phosphorylation in MECs of different genotypes by using an antibody specifically recognizing Rb proteins phosphorylated at Ser608 by CDK4 and CDK6 [XREF_BIBR, XREF_BIBR], the functional targets of p16."