IndraLab

Statements

USP6 is methylated. 6 / 6
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sparser
"In contrast with observation from mammalian systems, arginine methylation of the budding yeast S. cerevisiae hnRNP-like proteins Npl3, Hrp1, and Nab2 promotes their proper nuclear export [ xref , xref ]."
22091396
sparser
"However, Rmt1 is known to bind and/or methylate a number of proteins that process and export mRNA; methylation of Rmt1 target proteins Npl3, Hrp1, and Nab2 promotes their dissociation from nuclear factors and facilitates their export from the nucleus. xref – xref This is consistent with RPS2’s known functions of processing and exporting 20S rRNA, a precursor for 40s ribosomal subunits. xref , xref Our observation that RPS2 R10 dimethylation increases tenfold in stationary phase suggests that the cell may be facilitating export of RPS2 from the nucleus."
24486316
sparser
"If methylated Nab2 and Hrp1 are part of a stable, cytoplasmic CLB2 messenger ribonucleoprotein particle (mRNP), this might suggest that interaction of CCR4-NOT with the CLB2 mRNP is not sufficient to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23706744
sparser
"Consistent with our observation that different hnRNPs fail to accumulate in the cytoplasm when Hmt1 is inhibited, the lack of Nab2, Npl3, and Hrp1 methylation may prevent their binding to CLB2 mRNA."
23706744
sparser
"Interestingly, methylated Hrp1 binds to the EE of mRNA with the same efficiency as its unmethylated counterpart, but the presence of RNA itself inhibits Hrp1 methylation, particularly if the RNA displays a strong binding affinity to Hrp1 [ xref ]."
39408571
sparser
"Although methylation of hnRNPA1 had a slight effect on nonspecific binding to homopolymeric RNA (Rajpurohit et al., 1994) , methylation of yeast hnRNP Hrp1 did not affect its affinity for a specific [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11461695