IndraLab

Statements

USP6 is methylated. 3 / 3
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"In contrast with observation from mammalian systems, arginine methylation of the budding yeast S. cerevisiae hnRNP-like proteins Npl3, Hrp1, and Nab2 promotes their proper nuclear export [ xref , xref ]."
22091396
sparser
"Although methylation of hnRNPA1 had a slight effect on nonspecific binding to homopolymeric RNA (Rajpurohit et al., 1994) , methylation of yeast hnRNP Hrp1 did not affect its affinity for a specific [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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sparser
"However, Rmt1 is known to bind and/or methylate a number of proteins that process and export mRNA; methylation of Rmt1 target proteins Npl3, Hrp1, and Nab2 promotes their dissociation from nuclear factors and facilitates their export from the nucleus. xref – xref This is consistent with RPS2’s known functions of processing and exporting 20S rRNA, a precursor for 40s ribosomal subunits. xref , xref Our observation that RPS2 R10 dimethylation increases tenfold in stationary phase suggests that the cell may be facilitating export of RPS2 from the nucleus."
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