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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RTK binds SHC, SOS1, and GRB2. 1 / 1

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"The IGF-I receptor is closely related to the insulin receptor although each has significantly different affinities for its cognate ligand. xref One branch of IGF-I’s mitogenic signaling involves the association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate Ras and the MAP kinase cascades (Raf, Mek, Erk). xref One of the endpoints of the MAP kinase pathways is the modification of ELK transcription factors, serum response factor (SRF) and AP-1."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...