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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PPP2CA leads to the dephosphorylation of AKT1. 2 / 2

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"It was also reported that the Akt pathway is down-regulated by C2-ceramide in the NGF-treated PC12 cells as a result of enhanced dephosphorylation of Akt1 by protein phosphatase (CAPP-PP2A) [ xref ]."

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"Suppression of PPP2CA enhanced (p < 0.05) VEGF induced AKT1, but not ERK1/2 phosphorylation, whereas inhibited (p < 0.05) FGF2 induced ERK1/2 and p38 MAPK and slightly attenuated FGF2 induced AKT1 phosphorylation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...