IndraLab

Statements

CYLD activates MAP3K7. 11 / 12
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"In an analysis of the mechanism of this finding, we noted first that TGF-beta-stimulated T cells lacking CYLD exhibit increased TAK1 and p38 mitogen activated protein kinase (MAP kinase) activity."
21931165
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"Reconstitution of Cyld -/- MEFs with Cyld (WT) restored transient Tak1 activation (XREF_FIG) and normalized IL-6 production."
22057290
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"Deubiquitinases A20 and Cezanne, but not CYLD, are induced by NF-kappaB to negatively regulate TAK1 and NF-kappaB activity by removing K63 polyubiquitin chains [XREF_BIBR]."
24443058
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"XREF_BIBR, XREF_BIBR Similarly, in a hepatocytespecific cylindromatosis deficient (CYLD Deltahep) mouse model, which typically has increased hepatocyte TAK1 and NF-kappaB activation, TAK1 deletion decreased HCC development."
30809789
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"Deficiency in ITCH or CYLD causes sustained activation of TAK1 and increased cytokine production in bone marrow derived macrophages, and tumorigenesis and metastasis of transplanted Lewis lung carcinoma, suggesting that sustained activation of TAK1 leads to the progression of non-small-cell lung cancer (NSCLC) [XREF_BIBR]."
28106845
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"Thus, it was logical to examine whether CYLD targets Tak1 and regulates its ubiquitination."
17548520
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"CYLD targets and inhibits the ubiquitin dependent IKKbeta kinase TAK1 and therefore prevents aberrant lymphocyte activation [XREF_BIBR, XREF_BIBR], while A20 dampens NF-kappaB activity by trimming K63-ubiquitin chains attached to MALT1 [XREF_BIBR, XREF_BIBR]."
23590831
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"In mature T cells, CYLD targets TAK1 for inactivation to downregulate IKK and NF-kappaB activation [XREF_BIBR]."
21119682
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"It has been reported that an adequate amount of CYLD impairs the progression of NASH by inhibiting TAK1 signaling, and the E3 ligase TRIM47 has been revealed to be a key regulator of CYLD degradation, revealing that both of the above targets could be significant for the treatment of NAFLD.92 Caspase Inhibitor : Emricasan is a caspase inhibitor which can reduce the portal hypertension via blocking the activation of inflammatory caspase and inhibiting hepatocyte cell death."
30828530
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"By using CYLD knock-out mice, a recent study shows that in TGF-beta-treated T cells, CYLD deficiency causes enhanced TAK1 and p38 mitogen activated protein kinase activities."
24756567
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"Expression of Cyld (WT) but not Cyld (Y485A) mutant restored transient Tak1 activation (XREF_FIG)."
22057290