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EGFR phosphorylates PTK2. 30 / 34
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"Eighteen hours after scrape wounding, addition of HB-EGF significantly increased relative protein levels of p-FAK (1.42 +/- 0.05 vs. 1.00 +/- 0.01, p = 0.019), whereas blocking of EGFR activity with AG1478 inhibited the expression of p-FAK (0.83 +/- 0.08 vs. 1.00 +/- 0.01, p = 0.046) and also abolished HB-EGF-induced phosphorylation of FAK (0.93 +/- 0.07 vs. 1.42 +/- 0.05, p = 0.025) (XREF_FIG)."
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"To investigate the mechanism of EGFRvIII-promoted cell migration, we tested the hypothesis that EGFRvIII could stimulate the phosphorylation of FAK by binding to FAK, and that the resulting activation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To investigate the mechanism of EGFRvIII-promoted cell migration, we tested the hypothesis that EGFRvIII could stimulate the phosphorylation of FAK by binding to FAK, and that the resulting activation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"High expression of EGFL7 in gliomas xref and in metastatic gastric cancer xref promotes the activation of the AKT and ERK pathways through the interaction in EGFR; in hepatocellular cancer xref EGFL7 promotes metastasis through activating FAK phosphorylation by binding EGFR."
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"However, FAK phosphorylation was abrogated by EGFR inhibition."
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"Notably, full-length kinase-inactive FAK or the exogenous FERM domain of FAK are readily transphosphorylated at Tyr-397 by a component of the activated EGF receptor complex [11] ."
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"High expression of EGFL7 in gliomas and in metastatic gastric cancer promotes the activation of the AKT and ERK pathways through the interaction in EGFR; in hepatocellular cancer EGFL7 promotes metastasis through activating FAK phosphorylation by binding EGFR."
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"Given these findings, HER2 promotes EGFR phosphorylation and Smad3 phosphorylation, which contribute to Fak phosphorylation leading to EMT."
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"While the inhibitory effects of Galectin-3, EGFR, Cyclin A 2 , Bcl-2, phosphorylated EGFR, AKT, smad1/5/8 and FAK were rescued following the adding of Galectin-3 protein to cells with EGFR knockdown o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"FAK can be transphosphorylated by activated EGFR, and FAK function is required for EGF stimulated chemotaxis and motility [XREF_BIBR]."
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"In order to study phosphorylation of FAK by EGF-R and alphavbeta3 activation, we determined p-FAK expression levels as a function of alphavbeta3/VN interaction and EGF-R activation by EGF."
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"We show that FAK positioned between ILK and EGFR activates EGFR, which in turn phosphorylates FAK, leading to a positive feedback loop in RCP induced ovarian cancer cell invasion."
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"Another research reported that heterodimerization of proMMP-9 with CD44 can activate EGFR, which leads to phosphorylation of its downstream effectors ERK, AKT, and FAK and favors cell migration and invasion."
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"We also noticed that 0.01-0.3 microM defactinib treatment in H292 cells induced paradoxical increases in FAK pY397 that were in alignment with increases in pEGFR, suggesting that FAK-kinase inhibition led to FAK hyperphosphorylation by EGFR."
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"Our data showed that prolonged EGF/EGFR signalling activation led to FAK phosphorylation and cytoskeletal re-organization, which further influenced the colony formation and invasion of HNSCC cells tra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We show that FAK positioned between ILK and EGFR activates EGFR, which in turn phosphorylates FAK, leading to a positive feedback loop in RCP-induced ovarian cancer cell invasion."
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"Collectively, our study shows for the first time that overexpression of Egfl7 in HCC and Egfl7 promotes metastasis of HCC by enhancing cell motility through EGFR-dependent FAK phosphorylation."
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"This study demonstrated that EGF/EGFR can phosphorylate FAK and induce EMT in colorectal cancer cells.As knowledge of miRNAs continues to grow, more than 1,000 miRNAs have been identified in human gene banks."
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"Notably, full-length kinase-inactive FAK or the exogenous FERM domain of FAK are readily transphosphorylated at Tyr-397 by a component of the activated EGF receptor complex [35] ."
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"The EGF receptor (EGFR) inhibitor also suppressed 17-PT-PGE2-upregulated FAK phosphorylation."
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"The EGF receptor (EGFR) inhibitor also suppressed 17-PT-PGE2-upregulated FAK phosphorylation."
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"Another finding of our study was the observation that CD73 enhanced invasion and metastasis of HNSCC cells, mediated by activation of EGF and EGFR signaling, and its downstream phosphorylation of FAK."
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"When combining NIR-PTT with anti-EGFR-GNs in EGFR positive MDA-MB-231 cells and tumors, we observed obstruction of the EGFR mediated intracellular signal pathway (low phosphorylated mTOR, AKT, ERK1/2 and FAK levels) involved in cell proliferation and survival, as well as strong anti-proliferative (low Ki-67 level) and apoptotic activity (high cleaved caspase-3 and TUNEL levels)."
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"HER2 and EGFR phosphorylate kinase-dead FAK to maintain cell migration and invasion."
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"Mechanistically, de4 EGFR significantly upregulated the extracellular regulated protein kinase, AKT, focal adhesion kinase (FAK) and Src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of E-cadherin."
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"However, treatment of the cells with PF573228 and a pharmacological inhibitor of EGFR, gefitinib, abrogated RCP induced EGFR, and FAK phosphorylation, respectively."
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"We also noticed that 0.01–0.3µM defactinib treatment in H292 cells induced paradoxical increases in FAK pY397 that were in alignment with increases in pEGFR, suggesting that FAK-kinase inhibition led to FAK hyperphosphorylation by EGFR."
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"Finally the C. pneumoniae infection leads to FAK1 activation XREF_BIBR, and it is conceivable that EGFR activation by Pmp21 induces phosphorylation of FAK, which also is involved in cytoskeleton regulation."
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"Importantly, we have also demonstrated that Egfl7 could promote the metastasis of HCC by enhancing cell motility through EGFR-dependent FAK (focal adhesion kinase) phosphorylation [ xref ]."
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"HER2 and EGFR phosphorylate kinase-dead FAK to maintain cell migration and invasion."
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