IndraLab
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TNFAIP3 inhibits cytokine production. 6 / 6
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"Porphyromonas gingivalis (P. gingivalis) , one of the keystone periodontal bacteria, can activate NF-κB signaling in macrophages and induce A20 expression in vivo when injected intraperitoneal cavity of mice and therefore it is included as a model oral bacteria in in vitro assays. ( xref ) Our results revealed that A20 inhibits pro-inflammatory cytokine production both in human and mouse macrophages infected with P. gingivalis through its effect on NF-κB signaling."