IndraLab

Statements

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"TNFAIP3 siRNAs also increase IL-5 cytokine production and mRNA expression in Type 2 innate lymphoid cells in vitro [13] ."
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"Given the relationship we observed between elevated TNFAIP3 and decreased TNF-alpha, the lower levels of TNFAIP3 in AxSpA subjects may contribute to excessive cytokine production in response to PRR agonists."
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"Downstream of TLR activation , Quercetin supplement decreased cytokine production by regulating NF-kappaB activation and possibly modulating A20 expression , in response to oral bacteria and TLR agonist challenge ."
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"Porphyromonas gingivalis (P. gingivalis) , one of the keystone periodontal bacteria, can activate NF-κB signaling in macrophages and induce A20 expression in vivo when injected intraperitoneal cavity of mice and therefore it is included as a model oral bacteria in in vitro assays. ( xref ) Our results revealed that A20 inhibits pro-inflammatory cytokine production both in human and mouse macrophages infected with P. gingivalis through its effect on NF-κB signaling."
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"We hypothesized that lower levels of TNFAIP3 contributes to excessive cytokine production in response to inflammatory stimuli in axial spondyloarthritis (AxSpA)."
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"We noted that A20 significantly inhibited poly(I:C)-induced cytokine production, and this effect was related to the inhibition of NF-κB signaling."
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"A20/TNFAIP3 is required for glucocorticoid-GR actions to maximally repress inflammatory cytokine production induced by TNF signaling ( Sasse et al., 2016 )."
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"Mechanistically, TNFAIP3 gene expression is transcriptionally up-regulated by glucocorticoid-GR in concert with RelA/p65 to suppress the inflammatory cytokine production ( Altonsy et al., 2014; Momtaz[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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