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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

HCN1 binds APBA1, APBA2, and APP. 1 / 1

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sparser

"Here, we report that i) X11 -/- /X11L -/- mice suffer from spontaneous epileptic seizures along with malfunction of HCN channel activity; ii) HCN1 can form a complex with APP and X11 or X11L in the murine brain; iii) HCN1 -/- gene knockout mice show enhanced Aβ generation; iv) overexpression of HCN1 in Neuro2a (N2a) cells decreases Aβ generation, whereas blockage of HCN1 channel activity in N2a cells restores the level of Aβ production; v) the level of HCN1 diminishes significantly in the temporal cortex of cynomolgus monkeys ( Macaca fascicularis ) during aging; and vi) HCN1 levels are significantly reduced in the brains of sporadic AD patients compared with the brains of age-matched healthy subjects."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...