IndraLab

"The translocation and stabilisation of USP10 is regulated by ATM-mediated phosphorylation of USP10 on Thr-42 and Ser-337."

"The translocation and stabilization of USP10 is regulated by ATM -mediated phosphorylation of USP10 at Thr42 and Ser337."

"A previous study indicated that nuclear translocation of USP10 was regulated by ATMmediated phosphorylation of USP10 at Thr42 and Ser337."

"AMPKα AMPKα increases its activity by mediating phosphorylation of Ser76 at the USP10 N-terminus. [15] ATM ATM mediates phosphorylation of USP10 at Thr42 and Ser337 and causes USP10's migration into the nucleus. [27] TRAF4 TRAF4 and p53 competitively bind to USP10 and inhibit usP10-mediated p53 deubiquitination. [73] AKT Co-stimulation by BCR and TLR1/2 initiates Akt-dependent phosphorylation of T674 in the USP10 NLS domain. [72] USP13/beclin-1 When USP10 and USP13 interact with beclin-1, the deubiquitination activity of USP10 can be increased. [53] MiR-138 MiR-138 binds to a conserved region of USP10's 3 -UTR and inhibits the accumulation of USP10 mRNA and protein expression level. [31] MicroRNA-191 MicroRNA-191 binds to the 3 -untranslated region of USP10 mRNA, reducing USP10 protein levels. [28] MiR-34a-5p MiR-34a-5p binds to the 3 -untranslated region of USP10 and reduces the expression of USP10. [79] G3BP Direct binding of G3BP to USP10 inhibits its ability to decompose ubiquitin chains. [56] HTLV-1 Tax The central region of Tax interacts with amino acids 727-798 in USP10, inhibiting the activity of USP10. [78] Daam1 negatively regulates USP10's DUB activity. [80] Estrogen Estrogen induces p53 degradation by regulating USP10 activity. [81] Overexpressed FOXO4 inhibits USP10 transcription and protein expression by binding to the bases 1771-1776 in the promoter region TSS of USP10. [82] Zhang et al. indicated that miR-34a-5p acted as a negative regulator of USP10, but the underlying mechanism of the microRNA's action remains largely unclear [79] ."

"A previous study indicated that nuclear translocation of USP10 was regulated by ATM-mediated phosphorylation of USP10 at Thr42 and Ser337. xref We compared the effects of T674E USP10 and T42E-S337D-USP10 on nuclear AID degradation using a dendra2 decay assay."

"In the case of DNA damage, the phosphorylation of USP10 at Thr42 and Ser337 mediated by ATM is essential for its translocation to the nucleus, where USP10 induces the deubiquitination of p53 and makes p53 work as a tumor suppressor (Fig. xref ). xref "

"Phosphorylation of USP10 on Thr42 and Ser337 triggers its translocation, enabling the deubiquitination, stabilization and activation of p53."