IndraLab

Statements


RPS6KB1 phosphorylates IRS1 on S312. 8 / 8
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reach
"P70S6K phosphorylates IRS-1 on S312 and/or S636 and S639."

sparser
"P70S6K can phosphorylate IRS-1 on S312 and/or S636/S639."

sparser
"P70S6K phosphorylates IRS-1 on S312 and/or S636/S639."

reach
"At low levels, amino acids increase Akt phosphorylation in isolated muscle cells and improve insulin sensitivity, but at higher concentrations amino acids strongly activate p70 S6 kinase 1 which directly phosphorylates IRS1 on inhibitory serine residues 312 and 636/639 and blunts Akt phosphorylation."

reach
"P70S6K can phosphorylate IRS-1 on S312 and/or S636 and S639."

reach
"IRS-1 is phosphorylated by S6K1 at Ser312 resulting in its dissociation from the IGF-1 receptor, and proteasome mediated degradation (Shi et al, 2005)."

reach
"When alternative IRS-1 sites, S307 and S312 are phosphorylated by S6K1, it enhances proteasomal degradation, also leading to insulin resistance."

sparser
"IRS-1 is phosphorylated by S6K1 at Ser312 resulting in its dissociation from the IGF-1 receptor, and proteasome-mediated degradation ( xref )."