IndraLab

Statements

Lipopolysaccharide increases the amount of USP18. 14 / 16
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"We next sought to determine whether TNF-alpha and LPS could induce USP18 expression in hepatocytes via the induction of IFN-alpha."
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"TNF-alpha and LPS treatment also led to augmented USP18 protein expression by Western blotting (XREF_FIG) and by intracellular staining (XREF_FIG to XREF_FIG)."
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"We observed that neither IFN-α, LPS, nor TNF-α induce much, if any, hepatocyte expression of IFN-α or IFN-γ, although the same doses induce strong expression of USP18 (Fig. 5)."
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"USP18 mRNA expression was induced by TNF-α and LPS but not by IL-6 or IL-10 (Fig. 1A)."
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"MacParland et al. showed that TNF-alpha or LPS could target USP18 expression and thus inhibit IFN signaling [XREF_BIBR]."
27227879
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"TABLE 1: Inhibition of inflammatory signaling impairs TNF-α- and LPS-induced USP18 expressionaFIG 1: USP18 expression is upregulated by TNF-α and LPS."
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"USP18 mRNA expression was induced by TNF-alpha and LPS but not by IL-6 or IL-10 (XREF_FIG)."
27009955
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"We next sought to determine whether TNF-α and LPS could induce USP18 expression in hepatocytes via the induction of IFN-α."
27009955
ctd
No evidence text available
22687549
bel
"LPS strongly activates UBP43 expression in macrophages, which is paralleled by changes in UBP43 protein levels."
11854279
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"TNF-α and LPS treatment also led to augmented USP18 protein expression by Western blotting (Fig. 1C) and by intracellular staining (Fig. 1D to F)."
27009955
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"Having shown that LPS and TNF-alpha stimulation increases hepatocyte USP18 expression, we then sought to determine whether we could pharmacologically inhibit the induction of USP18 by LPS and TNF-alpha."
27009955
ctd
No evidence text available
25890327
ctd
No evidence text available
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