IndraLab

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COPS5 increases the amount of COPS5. 13 / 14
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"Thus, disruption of the Jab1 gene not only abolished JAB1 expression but also increased p27, p53 and c-Myc levels and cell death, suggesting that JAB1 is involved in maintaining the integrity and stability of critical regulators of cell proliferation and apoptosis."
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"Both shRNA of CSN5 (sh36/sh37) significantly inhibited CSN5 expression and cell proliferation in three AR-positive cell lines (LNCaP, C4–2, 22Rv1) (Figs."
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"Since JAB1 knockdown significantly decreased nuclear JAB1 expression, but not clearly decrease cytoplasmic JAB1 expression, the decrease in nuclear JAB1 expression may cause the decrease in nuclear β-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Herin, METTL3 overexpression could increase the m 6 A methylation levels of COPS5, stabilizing COPS5 mRNA and upregulating COPS5 expression."
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"It was found by Western blot analysis that at a concentration of 100 nmol/L, siRNA JAB1 reduced the expression of JAB1 protein by more than 90% ( Figure 2A , top), whereas the control scrambled siRNA [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These findings suggest that JAB1 induces the expression of JAB1 itself in addition to β-catenin/TCF4 and STAT3 targets including c-MYC.In conclusion, we have demonstrated that JAB1 positively regulate[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mechanistically, CCL5 leads to the formation of the nuclear factor κρρa p65/STAT3 complex, which binds to the COP9 signal 5 (CSN5) promoter to upregulates CSN5 gene expression."
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"The loss of csn-5 does not decrease the levels of a related PUF protein PUF-3 and csn-5(lf) phenotype is not enhanced by fbf-1/2 knockdown, suggesting that the effect is specific to FBFs."
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"To address the role of Jab1 and Sec6 in more depth, further research is needed to investigate how Jab1 modulates p27 phosphorylation at Thr157 and Sec6 regulates Jab1 expression.In a previous study, w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that pJab1 plasmid specifically targeting Jab1 gene expression could be an effective therapy for human laryngeal carcinoma."
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"Firstly, we co-transfected cells with sh-COPS5 (COPS5 knockdown) and METTL3 OE (METTL3 overexpression), and determined METTL3 and COPS5 expression first; Fig. 6 A–B shows that COPS5 knockdown caused n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"JAB1 knockdown caused a significant decrease in the expression of nuclear JAB1 and nuclear β-catenin, but not TCF4 ( Fig. 2 A, B, 2C, and 2D)."
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"As indicated in Fig. 7 A-B, COPS5 overexpression caused no changes in METTL3 expression but notably promoted COPS5 expression, whereas METTL3 knockdown observably inhibited METTL3 and facilitated COPS[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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