IndraLab
Statements
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"This suggests that pJab1 plasmid specifically targeting Jab1 gene expression could be an effective therapy for human laryngeal carcinoma."
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"Silencing of CSN5 mRNA using siRNA decreased the endogenous protein level of CSN5 and activated L-type Ca (2+) channels expressed in COS7 cells."
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"To address the role of Jab1 and Sec6 in more depth, further research is needed to investigate how Jab1 modulates p27 phosphorylation at Thr157 and Sec6 regulates Jab1 expression.In a previous study, w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both shRNA of CSN5 (sh36/sh37) significantly inhibited CSN5 expression and cell proliferation in three AR-positive cell lines (LNCaP, C4–2, 22Rv1) (Figs."
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"Thus, disruption of the Jab1 gene not only abolished JAB1 expression but also increased p27, p53 and c-Myc levels and cell death, suggesting that JAB1 is involved in maintaining the integrity and stability of critical regulators of cell proliferation and apoptosis."