IndraLab
Statements
reach
"Given parasites including E. histolytica express cullins and Nedd8 proteins XREF_BIBR - XREF_BIBR, it is plausible that JAB1 in parasites regulate cullins by deneddylation and modulate ubiquitin proteasomal system (UPS) activity, however, further studies to confirm this are needed."
reach
"Independently, IFIT proteins may modulate expression of negative regulators of the cell cycle, resulting in the accumulation of cells at the G 1 / S phase transition 60; ectopic expression of IFIT3 in U937 human myeloid cells resulted in sequestration of c-Jun activation domain binding protein-1 (JAB1), which limited ubiquitin and proteasome dependent degradation of cyclin dependent kinase inhibitor 1B (also known as p27 or KIP1)."