IndraLab

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COPS5 activates Ubiquitin. 8 / 8
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"These 2 genes, the well-known oncogene MYC and CSN5 (activator of ubiquitin ligase complexes) work together in activating the wound-response gene expression signature."
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"A notable role of JAB1 is modulating the activity of cullin-RING ubiquitin ligases (CRLs)."
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"Because Jab1 plays a central role in CSN-mediated deneddylation of the Cul1 subunit and subsequent regulation of the SCF (Skp1-Cullin-F box protein) ubiquitin ligase [14,15] , we examined the neddylat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"3 , 4 , 5 CSN5 is a deubiquitinating enzyme that can mediate the removal of Ub from Ub‐conjugated substrate proteins."
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"For instance, JAB1 was reported to modulate ubiquitin-dependent protein sorting into exosomes by mediating de-ubiquitination of HSP70 and Snail (Liu et al. 2009; Wu et al. 2009)."
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"Given parasites including E. histolytica express cullins and Nedd8 proteins XREF_BIBR - XREF_BIBR, it is plausible that JAB1 in parasites regulate cullins by deneddylation and modulate ubiquitin proteasomal system (UPS) activity, however, further studies to confirm this are needed."
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"In mice, cardiac specific knockout of COPS5 disrupts the ubiquitin–proteasome pathway, resulting in impaired autophagy and accumulation of misfolded protein aggregates."
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"In a previous study, we showed that PKA (cAMP-dependent protein kinase A) may phosphorylate BRSK2 at Thr260 and increase cellular BRSK2 levels [23] and Jab1 could interact with BRSK2 and promoted its [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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