IndraLab

"In the presence of an inhibitor of farnesly transferase (Ftase-1), which prevent the maturation of Ras, both Estradiol and TGF alpha induced ERK activation was significantly inhibited."

"stimulation of Erk by alpha6beta4 was suppressed by dominant-negative Shc, Ras and RhoA"

"p38 MAPK is activated in a ERK-dependent fashion, thus indicating that Ras promotes premature senescence by sequentially activating the ERK and p38 MAPK pathway [68]."

"Thus, altogether these results suggest that, although Ras may be involved in the initial phase of ERK activation by TPO, other pathways are required to maintain ERK activation for prolonged periods"

"Lysophosphatidic acid (LPA) is the prototypic G-protein-coupled receptor agonist that activates the Ras-mitogen-activated protein (MAP) kinase cascade"

"3CH134 protein, and the protein synthesis inhibitor cycloheximide leads to persistent activation of MAP kinase. 3CH134 blocks phosphorylation and activation of p42MAPK mediated by serum, oncogenic Ras, or activated Raf"

"Ras is involved in CpG ODN signaling as an early event by associating with TLR9 and promoting IRAK1/TRAF6 complex formation, and MAPK and NF-kappaB activation."

"Figure 5. This is a figure in the review representing the cross talk between FGFR3 and IL6 signaling in multiple myeloma cell line KH11; the legend is as follows: Fig. 5. Enhanced proliferation of myeloma cells by interleu- kin- 6 cooperatingwith FGFR3-mediated signals. IL- 6 and FGF induce the distinct intracellular signaling pathways in myeloma cells carryingt(4 ;14)(p16. 3 ;q32) that ectopically express FGFR3. FGF and IL- 6 activate ERK1/ 2, PI- 3 kinase and STAT3, respectively. The serine phosphorylation of STAT3 via the FGF- induced ERK1/ 2 activation contributes to the full activation of STAT3, leadingto the expression of c-myc and bcl- 2 genes and cell proliferation 91 .FRS:FGF receptor substrate."