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RAF1 activates MAPK1. 15 / 30
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"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal-regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
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"The action of the constitutively active Raf-1 was to stimulate the ERK2 kinase, whereas the dominant negative version of Raf- 1 inhibited the ERK2 activation induced by triggering of the TCR."
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"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
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"The evolutionarily conserved canonical mitogen-activated protein kinase (MAPK) signaling cascade—composed of the MAP3Ks ARAF, BRAF, and CRAF/RAF1 that phosphorylate and activate the MAP2Ks MEK1 and MEK2, which in turn phosphorylate and activate the MAPKs ERK1 and ERK2—drives a diverse array of cellular processes."
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"e phosphorylation of MEK1 and MEK2 could be stimulated by RAF1, which in turn activates the ERK1 and ERK2 to control cell cycle, apoptosis, and cell migration [34, 35] ."
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"Mammalian cells contain three Raf genes encoding the serine/threonine protein kinases, i. e. A-Raf, B-Raf, and Raf-1, that function as MAPK kinase kinase to initiate the ERK2 and ERK1 signaling cascad[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Activation of Ras and Raf-1 would then result in activation of ERK-1 and ERK-2."
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"12,13 Raf-1-dependent activation of ERK1 and ERK2 has been demonstrated in wounded intestinal epithelial monolayers, 37 in mec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, blockade of Raf-1 kinase function by overexpression of the dominant negative mutant of Raf-1 kinase completely inhibited ET-1-induced ERK2 activation."
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"Thus catalytically inactive Raf-1, a direct target of GTP-Ras, expressed in Jurkat cells blocked TCR mediated activation of a co-expressed ERK-2 kinase reporter, suggesting that the TCR activates the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RAF1 proto-oncogene serine/threonine protein kinase (RAF1) can activate ERK (official gene symbol MAPK1) and/or nuclear factor-kappa B (NF-kappaB) to regulate genes involved in inflammation."
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"A ceramide activated protein kinase (CAPK) phosphorylates Raf-1, which in turn activates an extracellular- signal regulated kinase 2 (ERK-2) type of mitogen activated protein kinase (MAPK), through th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation."
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"Both TPL2 and RAF1 activates ERK1 and ERK2 via the phosphorylation of their direct upstream activator, MAPK kinase (MKK) 1/MKK2 (also known as MAP2K1 and MAP2K2 XREF_BIBR."
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"Whereas enforced expression of c-Raf strongly activates ERK1 and ERK2, overexpression of MEKK1 only slightly stimulates the activity of both kinases (9)."
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