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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutation domain inhibits ZUP1. 1 / 1

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eidos

"A mutation in the SAP domain ( I83A / L86A ) , was previously reported to abolish the ability of Lpro to suppress type I IFN expression , to degrade signaling proteins ( i.e. NF-kappaB p65 , IRF3 and IRF7 ) , and to disrupt its DUB activity [ 36,37,39 ] , and was therefore included in our screening ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...