IndraLab

Statements

Modified AKT3 decreases the amount of TSC2. 3 / 3
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"Overexpression of AKT3 also increased protein abundance of phospho-AKT S473, phospho-AKT T308, and B-Raf but decreased expression of TSC1 and TSC2 proteins in LNCaP, DU-145, and CA-HPV-10 PCa cells."
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"Overexpression of AKT3 proteins decreased protein expression of TSC1 and TSC2 but increased protein abundance of phospho-AKT Ser473, phospho-AKT Thr308, and B-Raf in PC-3, DU-145, CA-HPV, and LNCaP PCa cells."
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"As overexpression of AKT3 decreased protein level of TSC1 and TSC2, we hypothesized that knockdown of TSC1 or TSC2 will enhance proliferation of prostate cancer cells."
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