IndraLab

Statements

HCN1 binds NF1. 9 / 9
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"Here, we have shown that NF1 interacts with HCN1 through its N-terminus, and that mutations in NF1 affect HCN channel function."
25917366
sparser
"Taken together, these results indicate that NF1 interacts with HCN1 through its N-terminal domain, but the N-terminal exon 9a is not required for this interaction."
25917366
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"Here, we have shown that NF1 interacts with HCN1 through its N-terminus, and that mutations in NF1 affect HCN channel function."
25917366
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"To examine the functional impact of the interaction between NF1 and HCN1 on hyperpolarization activated cation current (I h), we measured I h in both inhibitory and excitatory neurons in the hippocampal CA1 area."
25917366
sparser
"To further investigate the interaction between HCN1 and NF1, we performed heterologous expression studies in HEK293T cells."
25917366
sparser
"To examine the functional impact of the interaction between NF1 and HCN1 on hyperpolarization-activated cation current ( I h ), we measured I h in both inhibitory and excitatory neurons in the hippocampal CA1 area."
25917366
sparser
"A Ras-independent function of neuronal NF1 has been previously identified in the Drosophila model of NF1, and in neuronal cultures from Nf1 mice, through alterations in cyclic adenosine monophosphate (cAMP) signaling. xref – xref Given that HCN channels are well-known to be regulated by cAMP, xref it is distinctly possible that the HCN1–NF1 interaction affects local changes in cAMP, which contribute to the attenuated I h current in interneurons of Nf1 mice. xref Further studies are needed to address these possibilities."
25917366
reach
"To further investigate the interaction between HCN1 and NF1, we performed heterologous expression studies in HEK293T cells."
25917366
reach
"Taken together, these results indicate that NF1 interacts with HCN1 through its N-terminal domain, but the N-terminal exon 9a is not required for this interaction."
25917366